| Purpose:We aim to investigate the clinical factors that affect the prognosis of overall survival(OS)of patients with high-grade parotid gland mucoepidermoid carcinoma(high-grade p MEC)and construct a nomogram for prognosis prediction.Subjects and method:Patients diagnosed as high-grade p MEC between 2004 and 2015 were reviewed from the surveillance,epidemiology,and end results(SEER)database.Independent prognostic factors for OS were identified by Univariate and multivariate Cox regression analysis.Nomogram was generated to predict the individual’s 3-,and 5-year OS rates by R software.Prediction ability was evaluated using time-dependent receiver operating characteristic(ROC)curves and model calibration was evaluated through calibration plots.Decision curve analysis(DCA)was used to assess the clinical usefulness and net benefit.Results:The results of univariate analysis demonstrated that Age,AJCC stage,T stage,N stage,M stage,extraparenchymal lesions,regional lymph nodes status,lymph node dissection status,radiotherapy,chemotherapy and surgery were significantly correlated with the OS(P<0.05).Multivariate Cox regression analyses showed that older age,advanced AJCC stage and positive regional lymph nodes were independent risk factors for OS.We found that radiotherapy and surgery were independent protective factors for OS(P<0.05).The nomograms showed accurate prognostic ability that individually predict 3-years and 5-years survival rates based on age,AJCC stage,regional lymph nodes status,radiotherapy and surgery.The area under the curve(AUC)of the nomogram used to predict the 3-year and 5-year survival rate were 0.779 and 0.793,indicating that the model had a good predictive power for the overall survival(OS)in high-grade p MEC patient.Conclusions:We constructed a prognostic nomogram to predict 3-and 5-year overall survival(OS)rates based on the SEER database and can assist clinicians to intuitively evaluate prognosis of high-grade p MEC patients. |
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