Changes In Brain Structure And Function In Bipolar Disorder: A Combination Of Voxel-based Morphometry And Pseudo-continuous Arterial Spin Labeling Imaging

Objective:By studying and analyzing the brain structure and brain function of patients with bipolar disorder without medication,and comparing the differences of cerebral gray matter volume and cerebral blood flow perfusion between patients with bipolar disorder and normal people,this paper discusses the pathophysiological process of bipolar disorder in brain structure and brain function,in order to provide basis for the clinical diagnosis of bipolar disorder.Methods:Based on the control experiment,the experimental data were obtained by pseudocontinuous arterial spin labeling(p CASL)and voxel-based morphometry(VBM).There were 23 patients with bipolar disorder in the experimental group and 23 normal people in the control group.The proportion of men and women in the experimental group was the same as that in the control group,and their age and years of education were similar.The subjects in the experimental group and the control group were scanned with high-resolution T1 weighted structure image and pseudo continuous artery spin labeled perfusion imaging to obtain T1 brain structure and brain perfusion imaging.Then the scanned images were preprocessed and statistically analyzed by dpabi and SPM(12)software,and the differences of gray matter volume and cerebral blood flow perfusion between the two groups were compared by region of interest based method.Finally,based on the t-test method of two independent samples,the basic data and clinical characteristics of the experimental group and the control group are analyzed,and the statistical results are obtained.The t-test of two independent samples was analyzed by SPSS(26.0)statistical software.The criteria for confirming the statistical significance of the analysis results are: the mass size ≥ 5 voxels,and the test level P < 0.05(fwe correction).Result:1.Gray matter volume comparison results: Compared with the control group,the experimental group showed decreased gray matter volume in left middle frontal gyrus,left inferior frontal gyrus,left dorsolateral superior frontal gyrus,right medial superior frontal gyrus,right dorsolateral superior frontal gyrus,right medial frontal gyrus and right middle frontal gyrus(mass size ≥5 voxels,P < 0.05,FWE correction).2.Cerebral blood perfusion comparison results: Compared with the control group,the experimental group showed decreased cerebral blood perfusion in the right occipital lingual gyrus(mass size ≥5 voxel,P < 0.05,FWE correction).Conclusion:1.Patients with bipolar disorder have reduced gray matter volume in left middle frontal gyrus,left inferior frontal gyrus,left dorsolateral superior frontal gyrus,right medial superior frontal gyrus,right dorsolateral superior frontal gyrus,right medial frontal gyrus,and right middle frontal gyrus,suggesting that patients with bipolar disorder have characteristic abnormal gray matter volume.2.In patients with bipolar disorder,local cerebral blood perfusion in the right occipital lobe was decreased,which may be related to cognitive function,suggesting that neurovascular unit dysfunction may be a pathophysiological mechanism.3.Patients with bipolar disorder have structural abnormalities in some brain areas and abnormal brain functions.The changes of brain function and brain structure are not consistent,and the changes of brain function and brain structure may have independent pathophysiological basis.4.The brain structure changes in patients with bipolar disorder are lateralized on the right side,which may be related to the lateralized hemispheric imbalance,which needs further experimental verification.