Epidemiological Characteristics Of Staphylococcus Aureus In Anhui Province

Staphylococcus aureus is a common bacterium that can cause a wide range of infections,from minor skin infections to serious bloodstream infections and organ infections.The increase in drug resistance in Staphylococcus aureus is a global problem.Methicillin-resistant Staphylococcus aureus(MRSA)is a widespread drug-resistant strain that poses a challenge for treatment.The aim of studying the epidemiology of Staphylococcus aureus is to understand the distribution and mode of transmission of this pathogen in the population,as well as trends in the occurrence and prevalence of diseases associated with this pathogen.This bacterium can cause a wide range of diseases,from mild skin infections to more serious cases such as pneumonia,septicaemia and endocarditis.Understanding the epidemiology of S.aureus campestris can help public health authorities and healthcare providers to take effective control measures to prevent the spread and prevalence of this pathogen in the human population,thereby reducing the morbidity and mortality of diseases associated with it.To study the epidemiological characteristics of Staphylococcus aureus in Anhui Province,214 clinical strains of Staphylococcus aureus were collected from Anhui Provincial Hospital with a view to providing a theoretical basis for the prevention and treatment of Staphylococcus aureus infections,the results of the study are as follows.1.214 clinically produced S.aureus isolates from different patients in Anhui Provincial Hospital were collected between September 2021 and January 2022.The highest number of male elderly patients were infected with S.aureus in this study,which may be related to the history of other diseases and low body resistance in elderly patients.The number of MRSA and MSSA in different departments of the hospital was counted and after statistical analysis it was concluded that the number of patients infected with MRSA in the intensive care medicine and general geriatrics departments was higher than the number of MSSA.2.The VITEK2 Compact System 3 was used to identify isolates,and 17 antibiotic sensitivity tests were done on 214 Staphylococcus aureus isolates,of which the highest resistance rate to penicillin was 95.8%,and the statistical analysis method showed that most MRSA had a higher resistance rate than MSSA;therefore,antibiotics should be used rationally to avoid more drug-resistant bacteria.3.By MLST typing method,40 ST typing was found in 214 clinical isolates of S.aureus,ST59 and ST6697 typing were the most widely distributed,and the detection rate of CC5 was higher than other clonal complexes.4.After detecting the MLST typing and drug resistance of 214 S.aureus strains,the drug resistance of S.aureus with different ST typing was counted,and finally it was concluded that the drug resistance rate of S.aureus with different ST typing was different.5.In order to detect the virulence of different ST subtypes of S.aureus,a haemolytic test was conducted on 214 clinical isolates,and the results showed that ST59 had a strong haemolytic capacity.It was concluded that Staphylococcus aureus isolates in Anhui Province have unique molecular characteristics and antibiotic resistance characteristics,and the antibiotic resistance characteristics may be related to local antibiotic use trends.