Chinese Children’s RMPP Based On Network Meta-Analysis Clinical Evaluation Study Of Treatment Plan

Objective: This paper will compare the mixed comparison and ranking of different treatment plans composed of different drugs of refractory mycoplasma pneumonia in children in China through reticular meta-analysis and the total efficiency,adverse reactions,fever regression time,cough disappearance time,lung raleous sound disappearance time,lung shadow disappearance time and hospitalization time in these seven outcome indicators.It provides evidence-based basis for the reasonable selection of treatment plans for refractory mycoplasma pneumonia in Chinese children.Methods: Through search terms such as "refractory mycoplasma pneumonia,drug therapy,randomized controlled research",the electronic database and other methods before January 1,2023 were retrieved by computer,including Pub Med,EMBase,Cochrane Central Regist.Er of Controlled Trials,Web of Science,CBM,CNKI,Wan fang,Wei pu on refractory mycoplasma pneumonia in children is managed through Endnote 20 and submitted according to INPLASY.The Meta-analysis application regulations screen the literature,and strictly abide by the inclusion and exclusion criteria in the process.The quality of the literature is reasonably evaluated through the Revised Cochrane risk-of-bias tool for randomized trials(ROB1),and the risk bias map is drawn through R4.2.2.Stata17.1software is used for reticular Meta-analysis to quantitatively synthesize the curative effect and adverse reaction rate of each treatment plan,as well as the improvement time of the main clinical symptoms,and compare the advantages and disadvantages of each treatment plan through probability sequencing.Result:1.In the end,77 papers were included,a total of 7,450 child RMPP patients,and 17 treatment plans composed of 11 drugs were included.All 77 articles mentioned the age and course of treatment of the researchers.Two articles used single-blind and double-blind respectively,and neither of them mentioned the distribution of hidden.2.A total of 73 papers report on total efficiency.The order of total efficiency from high to low probability is azithromycin + methylone + third-generation cephalosporin,azithromycin + methylone + gamma globulin,azithromycin + globulin + dexamethasone,azithromycin + megonylon + rifampicin,azithromycin + dexamethasone,azithromycin +methylprednisolone + pidomod,azithromycin + gamma globulin,azithromycin +rifapentines,methyl prednisone and azithromycin sequential therapy.3.A total of 47 papers have reported adverse reaction rates.In terms of adverse reactions,from high to low probability,azithromycin + minocycline + methamphetamines,azithromycin + dexamethasone,azithromycin + hydrocortisone,azithromycin + thymus pentapeptide,azithromycin + gamma glob Method,azithromycin + pidomod,azithromycin+ gamma globulin,azithromycin + rifampicin,azithromycin + third-generation cephalosporin,azithromycin + metapleurons + pidomod and monomethamphetamilon.4.A total of 68 papers report on the heat drop time.In terms of reducing the heat regression time,the high to low probability ranking is azithromycin + gamma globulin +methamphotericin,azithromycin + gamma globulin + dexamethasone,azithromycin +third-generation cephalosporin + mesythronylon,azithromycin + rifampicin +methylprednisolone,azithromycin + nitemisin,azithromycin + hydrocortisone,azithromycin + dexamethasone,azithromycin + third-generation cephalosporin,azithromycin + pidomod,azithromycin sequential therapy,azithromycin + rifampicin and azithromycin + minocycline + methylprednisolone.5.A total of 60 papers report the time when the cough disappears.The probability of cough disappearance time is sorted from high to low: azithromycin + gamma globulin +dexamethasone,azithromycin + globulin + globulin + azithromycin + thymus pentapeptide,azithromycin + third-generation cephalosporin + methylnylon Cherithromycin + netimicin,azithromycin + rifampicin,azithromycin + hydrocortisone,azithromycin + dexamethasone,azithromycin + rifamphotrepine + mepine,azithromycin + third-generation cephalospor6.A total of 37 papers report the absorption time of lung tow.The probability sequencing of lung resorption time from high to low is azithromycin + dexamethasone,azithromycin + gamma globulin + metholone,azithromycin + globulin,azithromycin +mesythronylon,azithromycin + Azithromycin + rifampicin + methylprednisolone,azithromycin + rifampicin,azithromycin sequential therapy,azithromycin + minocycline+ methampicone.7.A total of 26 papers report the absorption time of lung shadows.The probability of lung shadow absorption time is sorted from high to low: azithromycin + gamma globulin+ metholone,azithromycin + gamma globulin + dexamethasone,azithromycin + thymus pentapeptide,azithromycin + globulin,azithromycin Methylon and azithromycin sequential therapy.8.A total of 39 papers report on the length of hospitalization.The probability sequencing of hospitalization from high to low is: azithromycin + rifampicin + amoxicillin,azithromycin + gamma globulin + mepronylon,azithromycin + globulin + dexamethasone,azithromycin + third-generation Protein,azithromycin + methamphenicone,azithromycin+ rifampicin,monomethampicone,azithromycin sequence therapy,azithromycin +minocycline + methamphenicone.Conclusion:1.The treatment plan containing glucocorticosteroids performed better in treating various outcome indicators of children’s RMPP,followed by the treatment plan with gamma globulin.The combined scheme of azithromycin + methylprednisolone + gamma globulin ranks in the top two in terms of various outcome indicators for the treatment of children’s MRPP.2.In terms of total efficiency,azithromycin + metholone + third-generation cephalosporin has the best treatment effect.In terms of adverse reactions,it is the safest to use naillon alone.In terms of reducing the heating time,the combined solution of azithromycin + globulin + methylprednisolone has the best effect.In terms of shortening the cough time,the combination of azithromycin + gamma globulin + dexamethasone has the best effect.In terms of reducing the disappearance time of lung tow,the combination of azithromycin and dexamethasone is the most effective.In terms of reducing the absorption time of lung shadows,the combination of azithromycin + gamma globulin +methylprednisolone has the best effect.In terms of shortening the hospitalization time,the combined scheme of azithromycin + rifampicin + methylprednisolone has the best effect.3.The treatment plan,which includes the third generation of cephalosporin,performed well in the total efficiency,adverse reaction rate,fever regression time,cough disappearance time and hospitalization time of RMPP in children,ranking in the top four.