| Introduction:Hypertension is one of the important risk factors for cardiovascular diseases.it is crucial to prevent and treat hypertension and the harm it brings.The aim of this paper is to investigate the correlation between lipoprotein(a)levels and hypertension and hypertensive target organ damage,as lipoprotein(a)is an independent risk factor for cardiovascular disease.Methods:This study included 1169 patients with simple hypertension and hypertensive target organ damage who attended the First Affiliated Hospital of Nanchang University from January 2018 to January 2022.One hundred and sixty-three healthy individuals who were physically examined during the same time period were included.Clinical data of all patients were collected,including general history taking information,and blood biochemical examination,urinalysis,carotid ultrasound,and echocardiography.All patients were divided into 389 patients with simple hypertension into grade 1,2,and 3 groups according to the diagnostic criteria of(Chinese Guidelines for the Prevention and Treatment of Hypertension,2018Revision);780 patients with target organ damage were divided into: 299 patients with hypertensive renal damage;221 patients with hypertensive left ventricular hypertrophy;and 260 patients with hypertensive carotid plaque formation.The clinical data of all the enrolled patients were statistically analyzed using SPSS26 statistical software.Results:1.There was a significant difference in the level of lipoprotein(a)in the simple hypertension group compared to the control group(p < 0.05).2.There was a statistically significant difference in the levels of lipoprotein(a)in the different levels of hypertension group compared to the control group(p <0.05).As the blood pressure level increased,the level of lipoprotein(a)also increased,and there was a difference in the group with grade 1 versus grade 3hypertension and grade 2 versus grade 3 hypertension(p< 0.05),while there was no statistical difference in the group with grade 1 versus grade 2 hypertension(p >0.05).3.Multifactorial logistic regression analysis revealed a significant correlation between lipoprotein(a)and hypertension.4.Compared with patients with hypertension alone,patients with combined target organ damage had higher lipoprotein(a)levels,and the difference between the two groups was statistically significant(p < 0.05).5.Lipoprotein(a)levels were not statistically significant in the comparison between patients with pure hypertension and those with hypertensive left ventricular hypertrophy(p> 0.05).6.Lipoprotein(a)levels were higher in patients with combined carotid plaque formation compared with the hypertension-only group,and the difference between the two groups was statistically significant p < 0.05).7.Spearman correlation analysis showed that lipoprotein(a)levels were negatively correlated with glomerular filtration rate levels and positively correlated with carotid plaque area,while there was no correlation with left ventricular mass index.8.Multi-factor logistic regression analysis showed that lipoprotein(a)was a risk factor for combined renal damage and carotid plaque formation in hypertensive patients(p < 0.05).9.After subgroup analysis,it was shown that in patients with hypertension combined with target organ damage,glomerular filtration rate levels were lower and carotid plaque area was larger when lipoprotein(a)≥300 mg/L.The difference was statistically significant(p < 0.05),while the difference in left ventricular mass index in the groups with different levels of lipoprotein(a)was not statistically significant(p > 0.05).Conclusion:1.Lipoprotein(a)levels were higher in the hypertensive group than in the healthy control group,while Lipoprotein(a)levels may correlate with blood pressure grading.2.Lipoprotein(a)levels were higher in patients with combined renal impairment and carotid plaque formation compared with the hypertension group alone,while left ventricular mass index did not correlate with lipoprotein(a)levels,while Glomerular filtration rate levels correlated negatively with lipoprotein(a)levels and carotid plaque area correlated positively with lipoprotein(a)levels.3.In hypertensive patients with existing associated target organ damage,the combination of high lipoprotein(a)levels may aggravate further target organ damage. |
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