Relationship Between β2 Microsphere Albumin And Relative Wall Hypertrophy In Patients With Primary Aldosteronism: A Cross-Sectional Study

Background:β2-microglobulin albumin(B2-MG)has been suggested as an emerging biomarker for cardiovascular diseases(CVD),which is an independent risk for coronary heart disease(CHD),atrial fibrillation,heart failure,peripheral arterial disease,and stroke.The aim is to explore whether elevated B2-MG levels were associated with relative wall hypertrophy change in Primary hyperaldosteronism.Methods:According to inclusion and exclusion criteria,We performed a cross-sectional study among Primary aldosteronism diagnosed in the Second Affiliated Hospital of Nanchang university between 2018 and 2022,included 692 Chinese Primary hyperaldosteronism patients.We analyzed the association between B2-MG and Left ventricular geometry change using multiple linear regression.Results:The median baseline B2-MG level in relative wall hypertrophy group 1.82 mg/L)was higher than that in the non-abnormal RWT group(1.68 mg/L,p<0.001,Wilcoxon rank sum test).Log2-B2-MG showed a significant positive association with abnormal RWT(odds ratio[OR] 1.76,95% confidence interval [CI95%](1.06,2.92)p=0.0290)).When B2M was divided into 5 groups according to quintiles,participants in the highest B2M quintiles had a multivariable-adjusted increased risk of relative wall hypertrophy compared to those in the lowest quintiles(odds ratio[OR] 2.05,95%confidence interval [CI] 1.08,3.88,p<0.05).Conclusion:High levels of B2M were increased probability of LV geometry change represented by relative wall hypertrophy in primary hyperaldosteronism,B2-MG is an independent risk factor of relative wall hypertrophy in primary aldosteronism patients.