Vitamin D Supplementation Reduces The Risk Of Type 2 Diabetes In Patients With Prediabetes:A Meta Analysis

Objective:To explore the effect of vitamin D supplementation on reducing the risk of type2 diabetes in prediabetic patients.Methods:By searching the Chinese biomedical literature database,Wanfang,CNKI,VIP database,Cochrane Library,Medine,EMbase,Pub Med,published vitamin D supplementation on the incidence of type 2 diabetes(Type 2 Diabetes,T2DM)randomized controlled trial(Randomized controlled trial,RCT),time from building to February 28 th,2021,root After screening the obtained literature according to the inclusion and exclusion criteria,data analysis was performed using Rev Man5.4software.Results:In this study,a total of 10 RCTs were included,included 5164 patients;Meta-analysis showed that vitamin D supplementation reduced the incidence of T2 DM in pre-diabetic patients,the difference was statistically significant(RR=0.89,95%CI:0.80-1.00;P<0.05).Subgroup analysis:1.Non-specific subgroup: after excluding specific populations(postmenopausal women,African-American military women,Asian obese women),the incidence of T2 DM in vitamin D supplementation in patients with prediabetes was similar to that in the control group,not statistically significant(RR=0.91,95%CI:0.81-1.02;P>0.05),while after the exclusion of obesity and postmenopausal populations,reduced incidence in the vitamin D group,and the difference was statistically significant(RR=0.88,95%CI:0.78-0.99;P<0.05);2.Subgroup with and without calcium intake: the incidence of vitamin D supplementation in the calcium-free group was not different from the control group,not statistically significant(RR=0.89,5%CI:0.79-1.00;P> 0.05),no difference in the vitamin D group compared with the control group in the calcium intake group,not statistically significant,not statistically significant(RR=0.89,95%CI:0.67-1.20;P>0.05);3.Different vitamin D dose subgroups: vitamin D ≥600U/d supplementation reduced the incidence of T2 DM and was statistically significant(RR=0.87,95%CI:77-0.99;P<0.05);4.Patient age subgroup: Vitamin D supplementation in the mean age <60 years significantly reduced the incidence of T2 DM in prediabetic patients,the difference was statistically significant(RR=0.60,95%CI:0.41-0.90;P <0.05),the mean age ≥60years did not show vitamin D supplementation reduction in T2 DM incidence in prediabetic patients,and the difference was not significant(RR=0.93,95%CI:0.82-1.06;P>0.05);5.Subgroups with different follow-up time: ≥2 years follow-up time group,The incidence of T2 DM was similar in the vitamin D supplementation and control groups,without statistically significant difference(RR=0.91,95%CI:0.81-1.02;P>0.05),the difference in the incidence of T2 DM in the vitamin D supplementation subgroup with follow-up time <2 years compared with the control group was not obvious(RR=0.64,95%CI:0.40-1.03;P>0.05).Conclusion:1.For patients with pre-diabetes,vitamin D supplementation can reduce the risk of type 2 diabetes in patients with pre-diabetes;2.Enough dose supplementation of vitamin D(600U / d)is effective in preventing the progression to type 2 diabetes in patients with pre-diabetes;3.Vitamin D supplementation was more effective in the prevention of type 2diabetes in young patients with prediabetes.