Clinical Epidemiological Analysis Of Non-Hodgkin Lymphoma With Cervical Mass As The First Symptom

Objective:This study investigates the clinical features,pathological typing,biochemical indices,imaging features,and treatment modalities of non-Hodgkin’s lymphoma(NHL)with a neck mass as the first symptom to enhance clinicians’ understanding of non-Hodgkin’s lymphoma and provide certain diagnostic experience for clinical work.Methods:The clinical data of 80 patients with NHL admitted to the Department of Otolaryngology,Head and Neck Surgery and the Department of Oncology and Hematology of Jilin University Baiquan First Hospital with a neck mass as the first symptom were collected and retrospectively analyzed between January 2012 and December 2022.The patients’ age,gender,lesion location,clinical manifestations,relevant examination results and treatment modalities were collected.Clinical staging of 80 patients was performed according to Ann Arbor staging guidelines.For the above clinical data,univariate and multifactorial analyses of NHL clinical staging were performed using SPSS software.Results:A total of 80 patients with NHL who had a neck mass as their first symptom were included in this study,including 47 male patients and 33 female patients,with a male-to-female ratio of 1.42:1.The age range of patients ranged from 7 to 85 years,with a mean age of 55 years and a median age of 56 years,and a high incidence age range of 61-70 years,with a median disease duration of 3 months.The onset of disease was on the left side of the neck in 42 cases,on the right side of the neck in 29 cases,and on both sides of the neck in 9 cases.80 patients had pathological typing,3 T-cell lymphomas and 77 B-cell lymphomas.There were 38 cases of diffuse large B-cell type(47.5%),25 cases of follicular type(31.3%),4 cases of marginal zone type(5.0%),1case of childhood follicular type(1.3%),5 cases of B small lymphocytic type(6.3%),4 cases of condyloma type(5.0%),1 case of angioimmunoblast T-cell type(1.3%),and2 cases of T-lymphoblast type(2.5%).80 patients clinical stage,25 patients(31.3%)in stage I,13 patients(16.3%)in stage II,17 patients(21.3%)in stage III,and 25 patients(31.3%)in stage IV.Eighty patients were divided into 66 patients in symptom group A(82.5%)and 14 patients in symptom group B(17.5%)according to the presence or absence of the following symptoms:fever >38.5°C lasting more than 72 hours without an infectious cause,night sweats,or weight loss >10% within 6 months.According to the univariate analysis,the presence of B symptoms and serum lactate dehydrogenase(LDH)could influence the clinical staging of NHL.To summarize,the neck ultrasound of NHL patients in this study was characterized by well-defined hypoechoic nodules with an internal lattice-like or flocculent distribution and abundant blood flow.Among the treatment modalities,15 patients chose surgery,and the remaining patients were treated with surgery,radiotherapy,chemotherapy,or a combination of treatment options.Conclusions:1.Non-hodgkin lymphoma with cervical mass as the first symptom is most common in 61-70 years of age,male;2.2.Diffuse large B-cell type is the most common pathological classification of NHL with neck mass as the first symptom;3.Serum LDH and B symptom are factors affecting the disease staging of non-Hodgkin’s lymphoma;4.NHL neck color Doppler features are characterized by clear boundary hypoechoic nodules,internal mesh or flocculent,and abundant blood flow.