Dynamic Variations In The Amplitude Of Low-frequency Fluctuations During Resting States With The Eyes Open And Closed In The Human Brain

Purpose: In recent years,growing studies have shown significant differences in static brain activity between eyes-open(EO)and eyes-closed(EC)in the resting state.However,there is no conclusive evidence to show whether the altered dynamic inner activity of the brain is clearly related to the state of the eye.The main purpose of this study is to investigate the changes of the dynamic amplitude of low-frequency fluctuation(d ALFF)in the human brain when the eyes are open and closed.Materials and methods: According to age,gender,and education level,26subjects(13 males and 13 females)with similar characteristics were screened.After being elaborated on the relevant risks,the subjects signed the paper informed consent.Each subject underwent scanning of rs-f MRI(resting state f MRI)respectively in the states of EO and EC.The d ALFF values of each brain region of volunteers under two eye states were calculated by sliding window analysis,and the dynamic changes of brain activity under EO and EC states were compared by two-sample T-test.Results: Compared with EC,the EO state displayed a decrease in d ALFF values in the left Parietal Inf.In contrast,the left Fusiform,both left and right Occipital Mid,the left Cerebellum 6,and the right Precentral showed increased d ALFF values in EO.This indicates that there are significant dynamic changes in the upper brain regions in EO and EC states.The d ALFF values’ regions underneath the ROC curve were: EC >EO,for Parietal＿Inf＿L 0.770(P < 0.001;95% CI: 0.648–0.893);EC < EO,for Cerebelum＿6＿L 0.758(P < 0.001;95% CI: 0.630–0.885);for Fusiform＿L 0.767(P <0.001;95% CI: 0.640–0.893);for Occipital＿Mid＿L 0.852(P < 0.001;95%CI: 0.745–0.959);for Occipital＿Mid＿R 0.810(P < 0.001;95% CI: 0.688–0.932);for Precentral＿R0.828(P < 0.001;95% CI: 0.716–0.940).Conclusion: By d ALFF technique,we found that there were significant differences in dynamic local spontaneous activity of subjects’ brains under EO and EC states.This study demonstrated the dynamic changes of local brain activity in the absence of light signal under physiological conditions,providing a basis for the correlation between pathological vision deprivation diseases and brain function changes.