The Correlation Between Serum Ferritin And Type 2 Diabetic Kidney Disease

ObjectiveThe purpose of this study was to investigate the relationship between Serum ferritin(SF),urinary microalbumin,long-term blood glucose,blood glucose fluctuation,blood lipid and oxidative stress in patients with Diabetic kidney disease(DKD),so as to provide clinical thinking for screening SF as early as possible and delaying the occurrence and development of DKD.MethodsA total of 233 type 2 diabetes(T2DM)patients from December 2019 to November 2022 were selected.According to the interquartile range of SF,it can be divided into:Q1 group :SF ≤ 116.2 ng/m L,n=58;Q2 group :SF 116.2 ～ 167.89ng/m L,n=59;Q3 group :SF 167.89 ～ 240.45 ng/m L,n=58;Q4 group: SF≥ 240.45 ng/m L,n=58.According to UACR staging: UACR < 30mg/g for normal albuminuria group,also known as simple diabetes group(group A,n=88);UACR 30-300 mg/g was microalbuminuria group(group B,n=100);UACR≥300mg/g was large albuminuria group(group C,n=45),BC group is also called DKD group.Clinical indicators of patients were collected.Finally,SPSS 23.0 statistical software was used to analyze all data.Results1.Comparison of clinical indexes among four groups of SFCompared with Q1 group,BMI,MBG,TAR,Hb A1 c,Tyg index,GSP,UACR and SCR were higher in Q3 and Q4 groups,and TIR was lower.There was no significant difference in Q2 group.TG of Q3 group was higher than that of Q1 group.The SOD in Q4 group was lower and older than that of Q1 group.FPG gradually increased with SF quartile,and e GFR gradually decreased,with statistical significance(P < 0.05).2.Comparison of clinical indicators among three groups of UACRCompared with A group,HDL-C was lower in B group,age,SUA and SBP were higher in C group,and SOD was lower.BMI,MBG,TAR,Hb A1 c,GSP,FPG,Tyg index,SF and SCR increased gradually with the increase of UACR,while e GFR and TIR decreased gradually,with statistical significance(P < 0.05).3.The correlation between SF and clinical indexesThe results showed that SF was positively correlated with age,BMI MBG,TAR,Hb A1 c,GSP,Tyg,FPG,TG,UACR,SCR and SUA.It was negatively correlated with HDL-C,TIR,e GFR and SOD,with statistical significance(P < 0.05)4.Linear regression between Log-MBG and Log-Hb A1 c and Log-GSP at different SF concentrationsConverting the natural logarithms of Hb A1 c,GSP and MBG,making them roughly conform to normal distribution.With the increase of ferritin concentration,the correlation between Log-MBG and Log-Hb A1 c gradually decreased.Similar findings were found in the correlation between Log-MBG and Log-GSP,with statistical significance(P < 0.05)5.Effectiveness of SF on blood glucose control in patients with DKDUnivariate binary logistic regression analysis was performed using the Hb A1c>7.5% in DKD as the dependent variable and age,sex,BMI,SBP,DBP,MBG,TIR,TBR,TAR,FPG,GSP,Tyg,FPG,SF,UACR,SCR,SUA,TC,TG,HDL-C,LDL-C and SOD as independent variables.These variables were included in multivariate logistic regression when P < 0.1.The results showed that FPG,and SF were independent risk factors for poor blood glucose control in DKD patients,while TIR,and HDL-C were independent protective factors,with statistical significance(P < 0.05)Conclusions:1.When SF level rises,the metabolism of glucose and lipid is disordered,and the antioxidant markers decreased,which may aggravate the progress of DKD.2.The level of SF increases with the progression of UACR,and SF can reflect the severity of kidney injury.In addition,SF is an independent risk factor for poor glucose control in DKD patients.3.With the increase of SF level,the response of Hb A1 c to real blood glucose may be affected,and better alternative indicators and related mechanisms need to be further explored.