| Objective:The role of intravenous dexmedetomidine in gastrointestinal function has been a controversial issue,and a review and meta-analysis of existing clinical randomized controlled trials was conducted to evaluate the effect of dexmedetomidine on postoperative gastrointestinal function recovery in patients undergoing abdominal surgery.Methods:Systematic literature search was conducted on Scopus,Web of science,the Cochrane Library,Pubmed,Ovid and VIP,Wanfang and China National Knowledge Network(CNKI)database from the establishment of the database to January 1,2023.Randomized controlled trial of the effects of intravenous dexmedetomidine on gastrointestinal tract after abdominal surgery.Two evaluators were responsible for independent literature screening,data extraction,and assessment of the methodological quality of the enrolled study,followed by meta-analysis with the software Rev Man5.4.Results:This meta-analysis included 10 studies,all RCTS,with a total of 1561 patients(dexmedetomidine group =790,group =771).The methodological quality of these RCTS ranged from low to high.The results of meta-analysis are as follows:1.In the first postoperative exhaust time,patients in the Dex group were significantly less than those in the control group,and the comparison result between the two groups was p<0.05,indicating a significant difference.2.The first postoperative defecation time of patients in dexmedetomidine group was significantly shorter than that in control group(p<0.05).3.In terms of the first feeding time after surgery,the Dex group was significantly less than the control group,showing a significant difference between the two groups(p<0.05).4.There was no significant difference in bowel sound recovery time between the two groups(p>0.05).5.The dosage of remifentanil in dexmedetomidine group was significantly lower than that in control group,and the difference was statistically significant(p<0.05);There was no significant difference in the dosage of sufentanil between the two groups(p>0.05).6.In terms of postoperative hospitalization days,Dex patients were significantly less than the control group,showing a significant difference between the two sides(p< 0.05).Conclusion:Intravenous dexmedetomidine can shorten the time of postoperative flatus and defecation and the time of first feeding,and also shorten the postoperative hospital stay of patients.This meta-analysis provides evidence that dexmedetomidine can promote the recovery of gastrointestinal function after abdominal surgery,but due to the limitation of the quantity and quality of the included literature,more large samples and high-quality studies are still needed to verify. |
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