| Objective:The purpose of this study was to compare the clinical effectiveness of these two methods in preventing infection in complex agricultural machinery injuries by comparing the conventional treatment method using debridement combined with VSD technique and debridement combined with vancomycin-loaded antibiotic bone cement in the treatment of complex agricultural machinery injuries.Methods:In this study,we retrospectively analyzed patients with complex agricultural machinery injuries admitted to the Department of Hand Surgery at China-Japan Union Hospital of Jilin University from September 2020 to December 2022,during the period from September 2020 to September 2021,we traditionally used multiple debridement combined with VSD to prevent and treat complex agricultural machinery injury infections,and from September 2021 to December 2022,we started to use multiple debridement combined with vancomycin-loaded bone cement was used to prevent and treat complex agro-mechanical injury infections.We collected and recorded a total of82 patients with complicated farm machinery injuries during this period,and after strict reference to the inclusion and exclusion criteria,60 patients,aged between 24 and 59 years,were finally included in this study.The patients were divided into an antibiotic bone cement group according to the treatment they received,a traditional treatment group using multiple adequate and thorough debridement combined with VSD treatment,and an antibiotic bone cement group using multiple adequate and thorough debridement combined with vancomycin-loaded antibiotic bone cement treatment.The endpoint of data collection in this study was that the patient had stable trauma infection control and completion of trauma repair,along with no subsequent surgery.The indicators that needed to be observed and recorded for treatment in the study included:routine blood,PCT,CRP,bacterial culture + drug sensitivity test results,number of surgeries,whether amputation was required,length of hospital stay,hospital expenses,and other inpatient indicators.The extracted data were created in an Excel database,and the measurement data were described as x± s.independent samples t-test was used for comparison between groups;repeated-measures ANOVA test was used for comparison between groups at multiple time points.Multiple comparisons were made using the Fubon Lenny correction test level,and if the data were severely skewed,the Mann-Whitney rank-order test was used for comparisons between groups,and the friedman test and Fubon Lenny correction test level were used for comparisons within groups.Count data were described as rates(percentages),and comparisons between groups were made using the χ2 test or fisher exact test.All test directions were twosided,and differences were considered statistically significant at P<0.05 to compare the therapeutic effect of vancomycin-laden antibiotic bone cement with conventional treatment modalities for the control of complex agricultural machine injury infections.Results:The experimental vancomycin-loaded antibiotic bone cement group showed significantly lower infection indicators than the control group with conventional treatment,with significantly fewer patients in the antibiotic bone cement group having positive bacterial cultures on the first,third,and fifth postoperative days than in the conventional treatment group,as well as lower white blood cell counts and PCT results,allowing for effective treatment and control of infection.In addition,the vancomycinloaded antibiotic bone cement group had a shorter total hospital stay,fewer procedures,and less cost.Conclusions:1.Vancomycin-laden antibiotic bone cement applied to complex agricultural injuries can shorten the length of hospital stay,reduce the number of procedures,and decrease the total cost of hospitalization for patients.2.Vancomycin-laden antibiotic bone cement applied to complex agricultural injuries can be effective in preventing and treating infections. |
PDF Full Text Request