| Background:The breast cancer incidence rate ranks first in female malignant tumours in China,and primary prevention of breast cancer should be taken into consideration as early as possible.Obesity is an important independent risk factor for breast cancer.Mobile health(m Health),which draws upon mobile devices for health-related apps,has emerged as a promising tool for health-related behavioral interventions.Previous literature had explored web-based and social media-focused obesity-related health behavioural interventions for helping reduce breast cancer risk in overweight and obese women.However,most relevant studies have disregarded individual preferences and personal characteristics.Thus,the interventions have shown limited benefit.Intervention studies in breast cancer prevention in Chinese women through behavioural health interventions have been very limited.Aims:The aims of the present study were:(1)To explore the efficacy of a personalized m Health behavioral intervention on reducing controllable risk factors for breast cancer(waist circumference,body mass index,body weight).(2)To explore the efficacy of a personalized m Health behavioral intervention on improving health behaviours(physical activity,fruit and vegetable intake behaviour)and reducing risk markers for breast cancer(C-reactive protein,relative telomere length).Methods:A randomized controlled trial design was used.Participants were recruited at two study sites,the Children’s Health Centre of the Third Xiangya Hospital of Central South University and the Health Management Centre of Hunan Provincial People’s Hospital,from July2020 to September 2020,respectively,with 40 participants included in each study site.The participants in each study site were randomized to an intervention group(N=20)and the control group(N=20).A total of 40 participants were included in the intervention group and 40 in the control group.The intervention group received a personalized m Health behavioral intervention,including face-to-face health education,We Chat-based personalized breast cancer prevention education,and personalized,tailored message intervention based on identifying healthy behaviour patterns.The control group received homogenized m Health education interventions with non-breast cancer prevention topics,including homogenized m Health education with non-breast cancer prevention topics and homogenized prompt message intervention with non-breast cancer prevention topics.Data on fasting waist circumference,body mass index,weight and physical activity level were measured at baseline,three months and six months.C-reactive protein levels and relative telomere length were collected at baseline and six months.Generalized estimating equation analysis was used to assess the efficacy of the intervention.Results:One hundred potential participants were recruited for this study,and finally,eighty participants were included.There were no statistical differences between the intervention and control groups in terms of demographic sociology,information related to breast cancer risk or outcomes variables(P > 0.05).At the end of the study,four people dropped out in the intervention group and six in the control group,and a total of ten participants dropped out in follow-up(12.5%).As predicted,the personalized m Health behavioral intervention had a significant time‐by‐group interaction effect on waist circumference,daily steps,daily moderate-intensity physical activity,daily high-intensity physical activity,and daily moderate to high-intensity physical activity in the intervention group compared with the control group over six months(P < 0.05).Conclusions:This is the first personalized m Health behavioral intervention on the breast cancer risk-reduction of obese women in China and effectively reduces the risk of controllable breast cancer in obese women.This approach may offer an innovative model to deliver the primary prevention programme of breast cancer among obese women in China.Future studies need to extend the follow-up period further and explore the long-term effects. |
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