Correlation Between Burst Suppression And Postoperative Delirium In Patients With Gastrointestinal Surgery

In recent years,postoperative delirium in postoperative patients has attracted widespread attention of clinicians.The slow recovery and high cost of postoperative patients caused by postoperative delirium have become one of the main reasons that affect the rapid recovery after surgery.In order to explore more risk factors related to postoperative delirium,this study took intraoperative anesthesia depth monitoring as an entry point to explore the correlation between intraoperative burst suppression and postoperative delirium.Objective: To explore the correlation between intraoperative burst suppression and postoperative delirium in elderly patients undergoing gastrointestinal surgery under general anesthesia using previous clinical data.Methods: Patients who underwent gastrointestinal surgery under general anesthesia in the Third Xiangya Hospital of Central South University from December 2018 to March 2020,underwent intraoperative anesthesia depth monitoring,and underwent preoperative and postoperative CAM scores were retrospectively collected.Clinical data included basic patient information,preoperative information,surgery and intraoperative anesthesia-related information,and postoperative information.According to the results of intraoperative anesthesia depth monitoring,patients were divided into BS group(intraoperative burst suppression)and non-BS group(The results of CAM scale and other related data of the two groups of patients were statistically analyzed,and the differences in the ratios of different original EEG waveforms between the two groups of patients were compared and analyzed.Results: In the baseline data of this study,86 patients included in the study were divided into two groups according to whether burst suppression occurred during surgery,and the baseline data were statistically analyzed.In the baseline data of the two groups of patients,only the age(p=0.003)was significantly different.Univariate logistic regression analysis was performed on the baseline data and outcome indicators of the two groups of patients.Except for age,which had an effect on the incidence of postoperative delirium,the other baseline data had no significant effect on postoperative delirium.Continue to conduct multivariate logistic regression analysis on the baseline data and outcome indicators that may affect the incidence of postoperative delirium,such as age,to verify that age does not affect the incidence of postoperative delirium in this study population under the confounding of multiple factors.The incidence of postoperative delirium(p=0.851)and other related outcome indicators were compared between the two groups(time of entering PACU after operation(p=0.8),length of hospital stay(p=0.935),whether or not to be admitted to ICU after operation(p=0.587))),were not statistically significant.Analysis of the original EEG of the two groups of patients showed that the full-band EEG energy of the patients in the burst suppression group was lower than that of the patients in the non-burst suppression group,and the difference was statistically significant.Conclusion: Intraoperative burst suppression in patients undergoing general anesthesia for gastrointestinal surgery is not related to postoperative delirium,but the occurrence of burst suppression is very likely to affect the brain function of patients.Except for postoperative delirium,the effects of burst suppression on postoperative PACU admission time,hospital stay,and postoperative ICU admission were small.