Clinical Observation Of Xinkeshu Tablet On PCI Patients With Non-ST Segment Elevation Acute Coronary Syndrome

Objective: To observe the therapeutic effect of Xinkeshu tablet on PCI patients with NSTE-ACS and to explore the possible mechanism.Methods: A total of 60 patients with NSTE-ACS diagnosed by the Department of Cardiology of Anhui traditional Chinese Medicine Hospital from December 2021 to November 2022 were included.The randomized grouping method was used to divide into control and treatment groups,with 30 cases each.The control group was treated with conventional NSTE-ACS western medicine,and the treatment group was treated with Xinkeshu tablet.Xinkeshu tablets were taken 2 tablets at a time,3 times a day,and warm water after meals.The curative effect of TCM syndrome,the score of TCM syndrome,the curative effect of angina pectoris,the curative effect of quality of life,the curative effect of ECG,the incidence of MACE events and the changes of cTnI,NT-proBNP,hs-CRP,LDL-C,TIMI blood flow grade and CTFC were observed before and after treatment.Results: 1.Comparison of efficacy of TCM syndrome,quality of life and TCM symptom score:The clinical symptoms of Xinkeshu Tablet + conventional western medicine group and conventional western medicine group were significantly reduced,and the efficacy of TCM syndrome,TCM symptom score and life quality score were significantly improved compared with before treatment,However,the improvement of TCM syndrome effect,TCM symptom score and quality of life score in Xinkeshu tablet+ western medicine group than in the western medicine group(P < 0.05).2.The curative effect of ECG and classification of angina pectoris: by comparison,the curative effect of ECG and the frequency and degree of angina pectoris in Xinkeshu tablet + routine western medicine group and conventional western medicine group were significantly better than those in the former group(P>0.05),but compared with the simple western medicine group,the curative effect of Xinkeshu tablet + western medicine group was better.3.Comparison of laboratory indexes: the level of cTnI in the two groups decreased significantly after PCI and after the course of treatment,and the levels of NT-proBNP,hs-CRP and LDL-C in the two groups were significantly lower than those before treatment,but the treatment group of Xinkeshu tablet plus western medicine was more obvious than that of the western medicine group.4.Comparison of TIMI blood flow grade and corrected TIMI blood flow count(CTFC):the number of patients with TIMI blood flow grade < grade Ⅲ in the two groups was similar,P > 0.05.There was no significant difference,which may be related to the small size of the observed sample.The level of CTFC in Xinkeshu tablet + western medicine group was significantly lower than that in western medicine group(P < 0.05).5.Comparison of MACE events: no MACE events occurred in the two groups of patients,but the reasons for short observation time and small sample size were not excluded.Conclusion: Xinkeshu tablet can effectively improve the TCM symptom efficacy,TCM syndrome score and ECG effect of PCI patients with non-ST segment elevation acute coronary syndrome,improve the quality of life of patients,and reduce the levels of CTFC,cTnI,NT-proBNP,hs-CRP and LDL-C.It is worth popularizing and applying.