Analysis Of Current Level And Related Factors Of Serum Vitamin A In Hospitalized Neonates

Objective:To understand the current level and deficiency of serum vitamin A in hospitalized neonates,to explore the influencing factors of vitamin A level in neonates,and to provide theoretical basis for the prevention and treatment of vitamin A deficiency in neonates.Methods:Neonates hospitalized in the neonatal intensive care unit of the Affiliated Hospital of Chengde Medical University from November 2021 to December 2022 were selected as the research objects.Venous blood samples were collected within 24 hours after birth,and vitamin A concentration was detected by high performance liquid chromatography-tandem mass spectrometry.The basic data of newborns and mothers were collected and grouped according to the inclusion and exclusion criteria,and statistical analysis was performed.SPSS 25.0 statistical software was used to analyze the vitamin A level of hospitalized neonates.The influencing factors of vitamin A deficiency in hospitalized neonates were explored by regression analysis.Outcome:1.The average level of serum vitamin A in 190 hospitalized neonates was 132.76 ± 48.99 ng / ml,and the incidence of vitamin A deficiency was90.0 %,including 122 cases(64.2 %)of subclinical deficiency and 49 cases(25.8 %)of clinical deficiency.2.There was no significant difference in serum vitamin A levels among hospitalized neonates with different gender,mode of delivery,gestational age,disease,premature rupture of membranes(P > 0.05).3.The serum vitamin A level of hospitalized neonates whose mothers were >35 years old was lower than that of hospitalized neonates whose mothers were ≤35 years old.The serum vitamin A level of hospitalized neonates without prenatal glucocorticoid application was lower than that of hospitalized neonates with prenatal glucocorticoid application.The serum vitamin A levels of newborns with birth weight of 1500-2500 g and2500-4000 g were lower than those with birth weight greater than 4000 g,the differences were statistically significant(P < 0.05).4.Maternal gestational diabetes mellitus was a risk factor for neonatal vitamin A deficiency(OR=9.799,95%CI=1.264-75.973,P=0.029),and antenatal glucocorticoids were a protective factor for neonatal vitamin A deficiency(OR=0.275,95%CI=0.099-0.768,P=0.014).Conclusion:1.The serum vitamin A level of hospitalized neonates is generally low,and subclinical vitamin A deficiency is common in hospitalized neonates.2.Serum vitamin A levels were lower in newborns of older mothers and diabetic mothers.3.Maternal gestational diabetes mellitus was a risk factor for neonatal vitamin A deficiency,and antenatal glucocorticoids were a protective factor for neonatal vitamin A deficiency.