Risk Factors Of New-onset Atrial Fibrillation In Patients With Severe Fever With Thrombocytopenia Syndrome During

Objective To study the occurrence of new-onset atrial fibrillation in patients with sever fever with thrombocytopenia syndrome(SFTS)during hospitalization fibrillation,NOAF)risk factors.Methods Medical records of 103 patients diagnosed with SFTS from May 2019 to June 2022 were analyzed,including 27 patients with new atrial fibrillation during SFTS hospitalization as the NOAF group and 76 patients without new AF as the non-NOAF group.Patient age,gender,peak temperature during hospitalization and whether community-acquired pneumonia was involved were recorded pneumonia CAP),history of Hypertension(HTN),history of type 2 diabetes(T2DM),And lymphocyte count(L),platelet count(PLT),platelet distribution width(PDW),mean platelet volume(MPV),platelet/lymphocyte ratio(PLR),alanine aminotransferase(ALT),aspartate aminotransferase(AST),lactate dehydrogenase(LDH),creatine kinase(CK),alpha-hydroxybutyrate deactivation Laboratory examination of hydroenzyme(HBDB),N-telencephalic natriuretic peptide precursor(NT-proBNP),activated partial thrombin time(APTT),thrombin time(TT),fibrinogen(FIB),D-dimer(DD),etc.Results Univariate analysis showed that the age of NOAF group and non-NOAF group [(74.5±7.8)years old,(66.4±10.9)years old],CAP[10(37.04%),10(13.16%)],PLT[33(14.8,66.6)109/L,45(31,)56)],LDH[900(410,2147)U/L,697(346,2119)U/L],CK[1005(141,7040)U/L,503(86,2752)U/L],NT-proBNP[2979(173,19219)pg/ml,642(67,5369)pg/ml] were statistically significant(P < 0.05).Multivariate logistic regression analysis found that old age(OR=1.07,95%CI1.00-1.14,P < 0.05),combined CAP(OR=8.22,95%CI 1.51-44.51,P < 0.05),NT-proBNP > 2000pg/ml for 2 consecutive days(OR=6.16,95%CI 1.31-28.84,P <0.05),CK peak > 6 times the upper limit of normal(OR=5.38,95%CI 1.03-28.17,P <0.05)was an independent risk factor for NOAF in SFTS patients during hospitalization.Conclusion Advanced age,combined CAP,2-day NT-proBNP >2000pg/ml,peak CK > 6× upper normal limit(ULN)are independent risk factors for new atrial fibrillation during hospital stay in SFTS patients.