| PurposeTo compare the prevalence of laryngeal reflux disease and gastroesophageal reflux disease among patients in the otolaryngology-head and neck surgery clinic and gastroenterology clinic,as well as the differences in clinical characteristics between patients of different genders and ages;To investigate the effect of combined gastroesophageal reflux disease on the clinical characteristics of laryngeal reflux disease.Methods1.Results of reflux disease-related scale survey based on gastroenterology outpatient clinics.Patients from the outpatient clinic of the Department of Gastroenterology at the Sixth Medical Center of the PLA General Hospital were included from March 2021 to April2021.All included patients completed the RSI and GERD-Q scales.Patients were divided into male and female groups;18-40,41-60,and over 60 years old groups;patients with pharyngeal reflux disease only(IL),patients with both pharyngeal reflux disease and GERD(L&G),patients with GERD only(IG),and normal(N)groups.Information on smoking history,alcohol consumption history,and preference for carbonated beverages,strong tea,or coffee was also recorded.The prevalence of GERD was compared with that of LPRD,and differences in RSI scores and GERD-Q scores were also compared between patients of different age groups,between patients of different genders,and between IL/L&G/IG/N groups.2.Survey study of reflux disease based on ENT outpatient clinicPatients from the outpatient clinic of the Department of Otolaryngology-Head and Neck Surgery at the Sixth Medical Center of the PLA General Hospital were included from March 2022 to April 2022.All included patients completed the RSS-12 and GERDQ scales.Patients were divided into male and female groups;18-40,41-60,and over 60 years old groups;patients with pharyngeal reflux disease only(IL),patients with both pharyngeal reflux disease and gastroesophageal reflux disease(L&G),patients with gastroesophageal reflux disease only(IG)and normal(N)groups.Information on smoking history,alcohol consumption history,and preference for carbonated beverages,strong tea,or coffee was also recorded.The prevalence of GERD was compared with that of LPRD,and differences in RSS-12 scores and GERD-Q scores were also compared between patients of different age groups,between patients of different genders,and between IL/L&G/IG/N groups.3.A study of the effect of 24-h-HEMII-p H monitoring based on combined GERD on the clinical features of laryngeal reflux diseaseThe data of 141 patients with symptoms of LPRD,118 males and 23 females,aged28-75(56.72±10.04)years,who attended the Department of Laryngeal Voice Surgery at the Sixth Medical Center of the PLA General Hospital from November 2020 to October2021 were retrospectively analyzed.The included patients underwent simultaneous 24-hHEMII-p H monitoring,multi-temporal salivary pepsin assay,RSI,and RFS.differences in 24-h-HEMII-p H monitoring parameters(acid reflux event parameters,weak acid reflux event parameters),positive salivary pepsin assay rate,and clinical signs and symptoms scores between patients in the IL group and those in the L&G were compared.Results1.Results of the reflux disease-related scale survey based on the gastroenterology outpatient clinicThe final number of patients included was 1974.There were 815 cases in males and1159 cases in females.There were 330 cases in the young population,975 cases in the middle-aged population,and 669 cases in the elderly population.Among them,48 cases(2.4%)were IL patients,306 cases(15.5%)were IG patients,90 cases(4.6%)were L&G patients,and the highest percentage of N was 1530 cases(77.5%).the incidence of GERD was 20.06%,and the prevalence of LPRD in GERD patients was 22.73%;the incidence of LPRD was 6.99%,and the prevalence of GERD in LPRD prevalence was 65.22% in GERD.Female patients had a higher prevalence of GERD.Male patients had significantly higher RSI scores and GERD-Q scores than women.The GERD-Q total score was significantly higher in the elderly group than in the young and middle-aged group(P < 0.05).the GERD-Q score was significantly higher in the L&G group than in the IG group(P < 0.05),and the RSI total score was significantly higher in the L&G group than in the IL group(P < 0.05).The three symptoms with the highest incidence in patients with positive reflux disease(those included in one of IL/L&G/IG)were acid reflux,burning sensation behind the sternum,and throat clearing.Simultaneous clinical characterization based on 24 h-HEMII-p H monitoring,reflux disease-related scales,and salivary pepsin assay2.Results of reflux disease-related scale survey based on outpatient otorhinolaryngology-head and neck surgery977 patients were finally included.There were 605 cases in males and 372 cases in females.There were 540 cases in the young population,259 cases in the middle-aged population,and 178 cases in the elderly population.60 patients with L&G(6.14%),221 patients with IL(22.62%),and 27 patients with IG(2.76%).the incidence of GERD was8.90%,the prevalence of LPRD in patients with GERD was 68.18%;the incidence of LPRD was 28.76% and the prevalence of GERD in LPRD was 21.28%.Male patients had higher rates of positive LPRD and positive GERD,and more male LPRD patients also had GERD.ear,nose and throat,gastrointestinal,and respiratory symptom scores,and quality of life impact scores were higher in older adults than in younger and middleaged adults(P < 0.05).l&g had significantly higher ear,nose and throat,gastrointestinal,and respiratory symptoms,and quality of life impact than did IG patients scores(P < 0.05),and the L&G group had significantly higher total RSS-12 scores than the IL group(P <0.05).The three symptoms with the highest incidence in patients with positive reflux disease(those included in one of IL/L&G/IG)were throat clearing,foreign body sensation in the throat,and acid reflux.2.Outcome analysis of the clinical characteristics of each group of patients based on 24 h-HEMII-p H monitoringBased on the 24 h-HEMII p H results,116 patients(82.3%)were diagnosed with LPRD and 45 patients(31.9%)with GERD,including 82 patients(58.2%)in the IL group,34 patients(24.1%)in the L&G group,11 patients(7.8%)in the IG group,and 14 patients(9.9%)in the N group.Based on the salivary pepsin test,a total of 108 patients had positive results,and the L&G group had a significantly higher rate of positive total salivary pepsin test(94.1%)and positive morning test(70.6%)than the IL group(75.6%,26.8%),IG group(63.6%,27.3%),and N group(35.7%,28.6%),with values of 19.01 and The RSI scores of patients in the L&G group(14.0)were significantly higher than those in the IL group(7.0),IG group(1.0)and N group(0),H=52.26,P<0.001.ConclusionThe prevalence of GERD was higher than LPRD in patients in the gastroenterology department,and the prevalence of LPRD was higher than GERD in patients in the otolaryngology-head and neck surgery clinic.the RSI scores and GERD-Q scores were significantly higher in male patients than in female patients in the gastroenterology clinic.GERD-Q scores were significantly higher in the elderly group than in the young and middle-aged groups.Among outpatients in the otolaryngology-head and neck surgery clinic,male patients had a higher rate of positive LPRD and positive GERD than female patients.Patients with both GERD and LPRD had more distinct clinical features,reflux events,and positive salivary pepsin test rates. |
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