Application Of Cardiac Magnetic Resonance Feature Tracking Technique In Left Ventricular Myocardial Strain In Patients With Hypertrophic Cardiomyopathy

Purpose: To analyze the myocardial mechanics in patients with hypertrophic cardiomyopathy(HCM)by cardiac magnetic resonance feature tracking(CMR-FT),and to explore the relationship between myocardial strain and left ventricular function and its diagnostic value in HCM patients.Materials and Methods: A total of 35 HCM patients and 41 healthy volunteers were enrolled in this study.HCM patients were divided into different subgroups according to whether ejection function was preserved and whether delayed reinforcement was present.Philips Intelli Space Portal software was used to obtain left heart function parameters on short-axis movie SSFP images.Post-processing software(CAAS MR Solutions 5.2.2)was used in the control group and the HCM subgroup for image post-processing,and the corresponding myocardial strain indexes were recorded.General clinical data and left ventricular function parameters of all subjects were collected.SPSS 26.0 software was used for statistical analysis of the parameters.Result: 1.Left ventricular global strain index values were progressively higher in the LVEF < 50% subgroup,LVEF ≥ 50% subgroup of HCM patients compared with control subjects,and lower in both subgroups compared with control subjects,with significant differences(P < 0.001).2.Left ventricular global strain index values were progressively higher among HCM patients in LGE +,LGE-and controls,and were smaller in both subgroups than in controls in both pairwise comparisons,a statistically significant difference,(P < 0.001)3 The peak myocardial global strain had better diagnostic efficacy for HCM,with the areas under the curve of GRS,GCS,and GLS of0.810,0.916,and 0.943,respectively.Conclusions:1.In HCM patients with normal left ventricular function(LVEF ≥50%),the values of left ventricular global myocardial strain,GRS,GCS,and GLS,were significantly decreased compared with control subjects;In HCM patients with reduced left ventricular function(LVEF < 50%),the value of left ventricular global myocardial strain decreased more significantly;Myocardial strain parameters obtained by the cmr-ft technique may thus allow earlier detection of impaired cardiac contractile function in patients with HCM and may reflect disease severity.2.Indexes of left ventricular myocardial global strain were numerically higher in the subgroups with and without reinforcement and in the control group in turn,and both the subgroups with and without reinforcement were smaller than the control group,indicating that in patients with HCM,myocardial contractile function is already impaired before fibrotic changes occur in the left ventricular myocardium,and therefore,early assessment of cardiac function by myocardial strain is significantly better than delayed enhancement analysis.3.There is a correlation between segmental myocardial thickness and longitudinal myocardial deformation ls in the mid left ventricle in patients with HCM.4.Indexes of left ventricular global myocardial strain have better diagnostic efficacy in patients with HCM.