Correlation Analysis Between Smoking And Gastric Cancer And Precancerous Lesions In Wuwei Cohort

Objective:By studying the smoking status,starting age of smoking,daily smoking dose,smoking years,smoking pack-years and smoking cessation years of the population in Wuwei area of Gansu Province,a region with a high incidence of gastric cancer,the relationship between smoking and gastric cancer,precancerous lesions and Helicobacter pylori was systematically expounded,and the role of smoking in the occurrence and development of gastric cancer was clearly defined.To provide scientific theoretical basis for establishing good living habits and prevention and control strategies of gastric cancer in high incidence areas.Method:According to the cross-sectional data of Wuwei natural population cohort,chronic non-atrophic gastritis and chronic atrophic gastritis,intestinal metaplasia and low-grade intraepithelial neoplasia,high-grade intraepithelial neoplasia,early gastric cancer and advanced gastric cancer diagnosed by pathological examination were selected as the research objects.The distribution characteristics of smoking in the general demographic data,diet,previous disease history,family history and Helicobacter pylori(Hp)infection were described.Different Logistic regression models were constructed to carefully analyze the correlation between smoking and gastric cancer,precancerous lesions and Hp infection.Results:1.There were differences in the distribution of smoking status in terms of sex and age,education level and marital status,occupational and household annual income,BMI and blood pressure,time of vegetable and fruit consumption,fast eating habits,and previous disease history.Male,age <50,high school education,married,nonagricultural,annual household income above 10000 yuan,BMI>28,normal blood pressure,fruits and vegetables within 1 to 4 months,fast eating habits,no previous hypertension,diabetes and gallbladder disease.2.Gender,age,occupation,blood pressure,vegetable and fruit time,and previous gallbladder disease were different in the age of initiation of smoking.There were differences in the distribution of daily smoking dose among different ages and nationalities.The distribution of smoking years was significantly different due to age,education level,marital status,occupation,household annual income,BMI,blood pressure,vegetable and fruit time,hot eating habit,fast eating habit,previous hypertension and diabetes,and Hp.The distribution of smoking pack-years differed by sex and age,education and occupation,household annual income and BMI,blood pressure,fast eating habits,previous hypertension,and diabetes.Different gender,age,blood pressure,fruit and vegetable time,previous hypertension and diabetes groups have different years to quit smoking.3.There was no statistical correlation between smoking status,daily smoking dose,smoking years,smoking pack-years and quitting years and CNAG-GAC.People who started smoking after the age of 25 had a 1.718 times higher risk of developing stomach cancer than non-smokers.4.Smoking was associated with the CAG-IM phase of the Correa cascade.Compared with never smokers,current smoking is the most important independent risk factor for the stage of CAG-IM.The younger the age at which smoking started,the greater the risk of IM.From the perspective of daily smoking dose,compared with never smokers,smoking <10 cigarettes a day increased the likelihood of getting IM,but did not reach statistical significance,while the risk of IM at 10-20 cigarettes a day and >20 cigarettes a day was 1.443 times and 1.496 times higher than that of nonsmokers.The longer you smoke,the more likely you are to develop IM.Smoking pack-years between 21 and 31 have the greatest risk of IM.The number of years of smoking cessation was not related to IM.5.There was no statistically significant correlation between smoking status,age of starting smoking,daily smoking dose,smoking years,smoking pack-years,quitting years and Hp infection.Conclusion:1.There are differences in the distribution of smoking status in Wuwei area.Smokers are mainly male,with high or middle school education,married,annual household income >10000 yuan,BMI>28,vegetables and fruits in 1-4 months,fast eating habits,no previous hypertension,no diabetes,no gallbladder disease and peptic ulcer.2.Initiation age of smoking >25 years old is an independent risk factor for gastric cancer.3.Smoking is an independent risk factor for the CAG-IM phase of the Correa cascade.People who started smoking before the age of 20 and after the age of 25 had the greatest risk of IM,and people who started smoking between the ages of 20 and 25 had a lesser risk of IM.Compared with never smokers,the risk of IM increased by1.443 times and 1.496 times for daily smoking doses of 10-20 and >20,respectively.The longer the years of smoking,the greater the risk of IM.4.Smoking is not an independent risk factor for Hp infection.