Analysis Of Traditional Chinese Medicine Syndrome Types And Medication Rules Of Type 2 Diabetes Mellitus Complicated With Constipation

Objective:In this study,the statistical software V3.0,an auxiliary platform for Chinese medicine inheritance,was used to statistically analyze the case data of patients with type 2 diabetes complicated with constipation in the endocrinology department of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine.Combined with the clinical diagnosis and treatment experience of the tutor,the prescription and medication rules of endocrinology department were summarized,which provided more ideas for clinical diagnosis and treatment of this disease.Methods:In this study,the medical records of patients who were diagnosed as type2 diabetes complicated with constipation in the endocrinology ward of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from October 2019 to December 2022 were collected,and the data were comp lete and up to standard.The collected information includes the patient’s basic situation,four diagnosis information,Chinese medicine diagnosis,western medicine diagnosis,syndrome,Chinese medicine composition and other information.The standardized data were entered into EXCEL tables by using the mode of two people and two computers,and data mining was carried out by using the related modules in V3.0,the TCM syndrome differentiation distribution,the frequency of commonly used drugs,the tropism and efficacy of drugs,the commonly used drug pairs and core prescriptions were summarized.Results:1.General situation: Among 161 patients with type 2 diabetes complicated with constipation,76 were male,accounting for 47.20%;85 cases were female,accounting for 52.80%.The ratio of male to female is 1: 1.12.2.Characteristics of onset: age distribution: 6 people aged 18-40,104 people aged 41-65,and 51 people aged over 66,mainly over 41 years old,accounting for 96.27% of all affected age groups;The course of type 2 diabetes mellitus is mostly more than 10 years,accounting for 49.69% of all the courses,and peripheral neuropathy is the most common complication,with 109 cases.3.Statistical results of TCM syndrome types: 38 cases of yin deficiency and intestinal dryness syndrome,accounting for 23.6%;35 cases(21.74%)were blood stasis blocking collaterals;30 cases of phlegm-heat syndrome,accounting for 18.63%;29 cases of gastrointestinal heat accumulation syndrome,accounting for 18.01%;29 cases of spleen and stomach qi deficiency syndrome,accounting for 18.01%.Among them,the syndrome of yin deficiency and intestinal dryness is the most,followed by the syndrome of blood stasis blocking collaterals,accounting for 45.34% of all syndromes.4.Statistical results of frequency of traditional Chinese medicine: The basic drugs commonly used in this disease are: Radix Astragali,Fructus Aurantii Immaturus,Radix Ophiopogonis,Radix Salviae Miltiorrhizae,Radix Rehmanniae,Radix Angelicae Sinensis and Poria,which are frequently used in various syndromes.5.The four therapeutic drugs are mainly cold,warm and flat,and the five flavors are mainly bitter,sweet and pungent.The meridian tropism of drugs mostly involves spleen,lung and stomach.The top five kinds of drugs are tonifying deficiency,clearing away heat,promoting blood circulation and removing blood stasis,promoting diuresis and eliminating dampness,and regulating qi.6.Analysis results of drug association rules: 15 drug patterns and 50 drug combinations were obtained,which were summarized into 4 categories: Ziyin Zengye group,Yiqi Jianpi group,Huoxue Huayu group,Qingre Huatan group,and Junxia heat accumulation group.7.Drug cluster analysis results: Combination 1: Radix Astragali,Fructus Aurantii Immaturus,Radix Angelicae Sinensis,Radix Salviae Miltiorrhizae,Fructus Cannabis,Cortex Magnolia Officinalis,Rhizoma Atractylodis Macrocephalae and Radix et Rhizoma Rhei.Combination 2: Fructus Trichosanthis,Rhizoma Coptidis,Rhizoma Pinelliae,Fructus Aurantii Immaturus,Radix Salviae Miltiorrhizae,Radix Polygalae,Radix Ophiopogonis and Poria.Combination 3: Radix Astragali,Fructus Aurantii Immaturus,Poria,Rhizoma Atractylodis Macrocephalae,Rhizoma Pinelliae,Rhizoma Alismatis,Cortex Magnolia Officinalis and Ramulus Cinnamomi.Combination 4: Radix Ophiopogonis,Radix Astragali,Radix Rehmanniae,Radix Scrophulariae,Poria,Radix Salviae Miltiorrhizae,Fructus Aurantii Immaturus,and Rhizoma Polygonati.Combination 5: Radix Astragali,Radix Rehmanniae,Radix Paeoniae Rubra,Lumbricus,Radix Angelicae Sinensis,Semen Persicae,Rhizoma Chuanxiong,and Flos Carthami.Combination 6:Radix Astragali,Radix Rehmanniae,Radix Angelicae Sinensis,Fructus Aurantii Immaturus,Poria,Radix Salviae Miltiorrhizae,Zingiberis Rhizoma,and Radix et Rhizoma Rhei.Conclusion:1.In this study,there are slightly more women than men with type 2diabetes complicated with constipation,and the onset age is mostly 41-65 years old.Patients with diabetes history of more than 10 years are more prone to constipation,and there are more patients with peripheral neuropathy.2.Traditional Chinese medicine syndromes of type 2 diabetes complicated with constipation are yin deficiency,intestinal dryness and blood stasis blocking collaterals,which are in line with the pathogenesis characteristics of the disease.3.The four therapeutic drugs are mainly cold,warm and mild,and the traditional Chinese medicines are mainly bitter,sweet and pungent.The meridian tropism of traditional Chinese medicines is mainly spleen,lung and stomach,and the efficacy of traditional Chinese medicines is mainly tonic,heat-clearing,blood-activating and stasis-removing,diuresis and dampnessregulating.The high-frequency drugs include: Radix Astragali,Fructus Aurantii Immaturus,Radix Ophiopogonis,Radix Salviae Miltiorrhizae,Radix Rehmanniae,Radix Angelicae Sinensis and Poria.