Professor Ma Jian’s Analysis And Experience Summary Of The Medication Rules Of Traditional Chinese Medicine In The Treatment Of Gout

Objective:Based on Professor Ma Jian’s clinical cases,the TCMICS was used to calculate the data,and through systematic analysis of Professor Ma Jian’s clinical treatment of gout prescriptions and medication,so as to explore and summarise Professor Ma Jian’s clinical experience in the treatment of gout and the rules of medication,with a view to providing new references for clinical treatment.Methods:Cases of gout patients who attended the outpatient clinic of Professor Ma Jian at the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from January 2018 to December 2021 and were within the inclusion criteria were recorded,sorted and excluded,and 105 medical records were integrated.The collated medical records were processed into templated data,and a standard database was established using the Excel standard template as a base,which was entered into the Traditional Chinese Medicine Inheritance Computer System V3.0(TCMICS V3.0)in chronological order of consultation.The patients’ personal information,the frequency of medication,the attribut-es of the four qi and five tastes of Chinese medicine,the attribution of the meridians,the relevant medication patterns and the clustering characteristics were statistically analysed to comprehensively analyse Professor Ma Jian’s medication pattern in the treatment of gout,and to summarise his clinical treatment experience and relevant academic concepts and ideas.Result:1.Among the 105 cases of gout,the number of cases in male patients was97(92.38%)and the number of cases in female patients was 8(7.62%),a ratio of 12.12:1.2.Of the 105 cases of gout,86 symptoms were obtained,with joint swelling and pain occurring most frequently.3.In 105 gout cases,nine tongue signs were obtained,dominated by a red tongue(105 times),white tongue coating(70 times)and a fat tongue with teeth marks(39 times).4.In 105 cases of gout,the patients had a total of 12 types of pulse,of which the main ones were smooth and stringent(41 times),sunken and slippery(23 times)and slippery pulse(15 times),representing a percentage of 87.88%.5.Among the 105 prescriptions of Chinese herbal medicines,a total of96 medicines were used,with Plantaginis herb and Smilax glabra Roxb being the most frequently used,and the remaining top three Chinese medicines in terms of frequency were dioscorea,dandelion and coix seeds.6.The four gases of Chinese medicine were predominantly cold 604times(45.15%),flat 305 times(22.46%)and warm 304 times(21.94%),representing a percentage of 89.65%.7.The five tastes of Chinese medicine were predominantly sweet 775times(40.01%),bitter 757 times(39.08%)and pungent 282 times(14.56%),representing a percentage of 93.65%.8.The frequency of Chinese herbal medicines to the meridians was greater than 300 times for the liver,lung,stomach,spleen and kidney meridia-ns respectively,accounting for 75.26%.9.The efficacy of Chinese medicine was mainly in the category of clearing heat 491 times,diuresis and dampness 330 times,tonifying deficienc-y 163 times,activating blood circulation and resolving blood stasis 106 times and resolving dampness 70 times,accounting for 85.73% of the total.10.Based on the association rule,the core drugs are: Plantaginis herb,Smilax glabra Roxb,Dioscorea alba,Coix seeds,Dandelion,Radix et Rhizoma tigrinum,Paeonia lactiflora and Phellodendron.11.Using the K-means algorithm,six core drug combinations can be derived: Group I: Plantaginis herb,Smilax glabra Roxb,Coix seed,Dandelion,Radix et Rhizoma tigris,Smilax glabra Roxb,Atractylodes macrocephala;Group II: Plantaginis herb,Smilax glabra Roxb,Atractylodes macrocephala,Hyssop,Radix et Rhizoma lactiflorum,Dandelion,Dioscorea alba,Phelloden-dron;Group III: Plantaginis herb,Smilax glabra Roxb,Dandelion,Dioscorea alba,Salvia miltiorrhiza,Coix seed,Atractylodes macrocephala,Red currant;Group IV: Plantaginis herb,Smilax glabra Roxb,Dandelion,Hyssop Dandelion,Astragalus,Coix lacryma,Dioscorea,Oxalis,Radix et Rhizoma;Group V: Coix lacryma,Dioscorea,Plantaginis herb,Poria hybrida,Dandeli-on,Herba Cyperus,Radix tigris,Radix et Rhizoma;Group VI: Coix lacryma,Dandelion,Herba Cyperus,Plantaginis herb,Poria hybrida,Herba Cyperus,Radix et Rhizoma.Conclusion:1.The herbs used by Professor Ma Jian in the treatment of gout are often based on clearing heat,diuresis and dampness,tonifying deficiencies,activat-ing blood circulation and resolving blood stasis,and resolving dampness,with the core prescriptions being:Plantaginis herb,Tu Fu Ling,Dioscorea,Coix Seed,Dandelion,Tiger Balm,Red Peony,and Huang Bai.2.In the treatment of gout,Professor Ma Jian applies the majority of sweet and bitter tasting herbal medicines,the majority of cold and flat tasting herbal medicines,and the majority of medicines classified in the lung,liver and stomach meridians.3.In treating gout,Professor Ma Jian classifies it into three types of symptoms: damp-heat-embedded syndrome,damp-heat-trapped spleen syn-drome and stagnant veins and channels.4.In the treatment of gout,Professor Ma Jian focuses on the treatment concept of clearing heat and removing dampness,together with the treatment methods of strengthening the spleen,invigorating Qi,invigorating blood and eliminating blood stasis,etc.In the process of diagnosis and treatment,he focuses on both the symptoms and the root cause,and on both attack and remedy.