Clinical Observation Of Qilianhuazhuo Tang Decoction In Treating Type 2 Diabetes Mellitus Complicated With Obesity (Evidence Of Spleen Deficiency And Stomach Heat)

Objective:By observing the improvement of glucolipid metabolism-related indexes and clinical symptoms in patients with T2 DM combined with obesity(evidence of spleen deficiency and stomach heat)treated with Qilian Huazhuo Tang,we objectively evaluated its efficacy and safety,and further provided a new Chinese medicine diagnosis and treatment basis for the prevention and treatment of T2 DM combined with obesity.Methods:In a randomized controlled study,70 patients who met the diagnostic criteria of T2 DM combined with obesity with spleen deficiency and stomach heat were randomly divided into treatment and control groups,with 35 patients in each group.The control group was treated with diet and exercise intervention and metformin hydrochloride,while the treatment group was treated with Qilian Huazhuo Tang orally on top of the control group for 8 weeks.8 weeks later,changes in TCM symptoms,blood glucose related index,fasting insulin and insulin resistance index,obesity related index and blood lipid index were observed in both groups before and after treatment,and statistical analysis was performed.Results:1.Efficacy and score of TCM symptomsThe overall effective rate of TCM symptoms in the treatment group and the control group were 87.5% and 59.37%,respectively,and the treatment group was better than the control group(P<0.01).After treatment,the accumulation of TCM symptoms decreased in both groups compared with that before treatment(P<0.01);compared with the control group,the decrease was more obvious in the treatment group(P<0.01).2.Blood glucose related indexesFBG,2h PG and Hb A1 c in both groups decreased after treatment compared with those before treatment(P<0.01);the degree of decrease of FBG,2h PG and Hb A1 c in the treatment group was more obvious compared with that in the control group(P<0.01).3.Insulin-related indicatorsFINS and HOMA-IR in both groups decreased after treatment compared with those before treatment(P<0.01);FINS and HOMA-IR in the treatment group decreased significantly compared with the control group(P<0.01).4.Obesity-related indicatorsThe body weight,BMI and waist circumference of both groups were decreased after treatment compared with before treatment(P<0.05).The decrease of body weight,BMI and waist circumference in the treatment group was better than that in the control group(P<0.05).5.Lipid related indicatorsThe indexes of TC,TG,and LDL-C in both groups decreased after treatment compared with those before treatment(P<0.05),while the indexes of TC,TG,and LDL-C in the treatment group were significantly lower than those in the control group(P<0.05).6.Total clinical efficiencyThe total effective rate of the treatment group was 84.37%.The total effective rate of the control group was 62.5%,and the total effective rate of the treatment group was significantly higher than that of the control group(P<0.01).7.Safety indexesAfter treatment,the blood,urine and stool routine,standard electrocardiogram and liver and kidney function indexes of the two groups were within the normal range,and there were no serious adverse reactions,suggesting that the drugs were safe.Conclusion:1.Qilian Huazhuo Tang can significantly improve the TCM clinical symptoms of T2 DM patients with obesity(spleen deficiency and stomach heat syndrome).2.Qilian Huazhuo Tang can reduce the levels of FBG,2h PG and Hb A1 c in T2 DM patients with obesity(spleen deficiency and stomach heat syndrome).3.Qilian Huazhuo Tang can improve insulin resistance and reduce FI NS and HOMA-IR levels in T2 DM patients with obesity(spleen deficiency and stomach heat syndrome).4.Qilian Huazhuo Tang can reduce the level of body weight,BMI and waist circumference in T2 DM patients with obesity(spleen deficiency and s tomach heat syndrome).5.Qilian Huazhuo Tang can improve the levels of TC,TG and LDL-C in T2 DM patients with obesity(spleen deficiency and stomach heat syndrome).