Exploring The Correlation Between Imaging Features And ASNR In Patients With Large Vestibular Aqueduct Syndrome

Objective : To investigate the influence of imaging features on acoustically evoked short latency negative response(ASNR)in patients with large vestibular aqueduct syndrome(LVAS).Methods:The imaging and audiology data of 26 patients(52 ears)with large vestibular aqueduct syndrome who visited the Department of Otolaryngology,the First Affiliated Hospital of Bengbu Medical College from January 2016 to April 2022 were retrospectively analyzed.Twenty-one cases(42 ears)with severe-to-very severe sensorineural hearing loss without inner ear deformity confirmed by temporal bone CT were used as the control group,and their imaging and audiological characteristics were analyzed.Results:(1)the extraction rate of ASNR in LVAS group and control group was44.2% and 9.5% respectively,and the difference was statistically significant.The average reaction threshold of ASNR was 91.57 ±7.25 d B n HL and 89.25±6.99 d B n HL,respectively,and the average latency was 3.36 ±0.35 ms and3.26 ±0.59 ms,respectively.(P>0.05)(2)In patients with LVAS,the diameter of external orifice of vestibular aqueduct in ASNR extraction group(23 ears)and non-extraction group(29 ears)was 4.01 ±1.09 ms and 4.06 ±1.02 ms,respectively(P>0.05),and there was no significant difference between ASNR drainage group and average reaction threshold.(3)The ASNR extraction rates of MRI endolymphatic sac type Ⅰ group,type Ⅱ group and type Ⅲ group were50.0%(4/8)、33.3%(4/12)和 46.7%(15/32),respectively,with no significant difference(P>0.05).The average response threshold of ASNR was 84.25±9.43,86.75 ±8.30,94.80 ±3.95 d B n HL,respectively.There was statistical significance between type Ⅰ group and type Ⅲ group,(P<0.05).The average incubation period was 3.07 ±0.14,3.43 ±0.13,3.23 ±0.29 ms respectively,and the difference was not statistically significant,(P>0.05).Conclusion:(1)LVAS patients have higher ASNR extraction rate than other sensorineural deafness patients.(2)The extraction of ASNR is not affected by the diameter of the external orifice of the vestibular aqueduct.(3)The extraction rate and latency of ASNR in patients with LVAS were not affected by the classification of endolymphatic sac of MRI.The average reaction threshold of ASNR in type Ⅰ group was lower than that in type Ⅲ group.