Clinical Efficacy And Correlation Analysis Of Short-term Intensive Insulin Therapy For Newly Diagnosed Type 2 Diabetes Mellitus

Object: To analyze the improvement of test results and the correlation between blood glucose,blood lipid and islet function in newly diagnosed type 2 diabetes patients treated with short-term intensive insulin regimen at different follow-up time points.Methods: The clinical data of 105 newly diagnosed patients with type 2 diabetes who were hospitalized in the Department of Endocrinology,the First Affiliated Hospital of Xinjiang Medical University from September 2021 to December 2022 were collected,and the patients meeting the inclusion criteria were treated with short-term intensive insulin therapy for 7-14 days.The changes of low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC),fasting blood glucose(FPG),postdietary 2h blood glucose(2h PG),fasting C-peptide(FC-P)and postdietary 2h C peptide(2HC-P)were observed before and after treatment.Body mass index(BMI),HOMA Insulin resistance index(HOMA-IR)and Homa-β function index(HOMA-β)were calculated.Results: 1)After treatment,FPG,2h PG and HOMA-IR were decreased compared with before treatment,while FC-P,2h C-P and HOMA-β were increased compared with before treatment,P < 0.05,which was considered to be statistically significant;2)After treatment,Hb A1 c,LDL-C,TG and TC were decreased compared with that before treatment(P<0.05),which was considered to be statistically significant;3)For newly diagnosed type 2 diabetes patients,if FBG<7mmol/L or Hb A1c<6.5%after withdrawal of hypoglycemic drugs for at least 3 months after the cessation of short-term intensive insulin therapy,only under the condition of controlling diet and appropriate exercise,after stopping short-term intensive insulin therapy,the clinical remission rate can reach 56.19%;4)HOMA-IR of newly diagnosed type 2 diabetes patients was positively correlated with age,BMI,LDL-C,TG,TC,fasting blood glucose,2h postmortem blood glucose and fasting C-peptide,but not with age and 2h C postmortem peptide,while HOMA-β was negatively correlated with age,LDL-C,fasting blood glucose,2h postmortem blood glucose and glycosylated hemoglobin.It was positively correlated with fasting C-peptide and postmeal 2h C peptide,but not with BMI,TG and TC.Conclusion: Short-term intensive insulin therapy for newly diagnosed type 2diabetes can rapidly relieve glucose toxicity,improve the secretion function of pancreaticβ cells and reduce insulin resistance.After 1 year of follow-up after intensive insulin therapy,the clinical remission rate reached 56.19% under the condition that drugs could be stopped or only metformin was taken orally by strictly controlling diet and increasing exercise.