| Objective:Anthracycline therapy（ANT）results in an asymptomatic decrease in left ventricular ejection fraction（LVEF）.However,the effect of Anthracycline on diastolic function in cancer patients is still not fully understood.This study investigated the effect of ANT on diastolic function and the relationship between diastolic function and systolic function.Methods:In a single-center retrospective study of 132 patients with blood tumors without heart disease who received Anthracycline therapy,GEE was used to assess changes in diastolic function,and the relationship between the change of diastolic function and LVEF.Kaplan-meier calculated the proportion of participants with diastolic dysfunction（DD）.The COX model estimates the relationship between participants’characteristics and DD risk.Results:At a median of 13（8,23）months of follow-up,patients who underwent ANT were followed up for 6 months,the ratio of early diastolic mitral flow velocity（E）to early diastolic mitral annular motion velocity（e’）increase slowly,but there was no significant difference.E,E and late diastolic mitral flow velocity（A）ratio（E/A）,ventricular septum e’(e’sep),and lateral wall e’(e’lat)all had a continuous and slow decline compared with the baseline value,among which E,e’lathad statistical significance at t=6 months.The incidence of DD was 10%in 1 year,20%in 2 years and33%in 3 years.This may indicate that the grading of diastolic function will change dynamically over time.The study also found a slight association between any abnormal E/e’elevation and a subsequent significant decrease in LVEF（Beta:-2.047;95%CI:-3.960,-0.133;P=0.036）,and increase in baseline E/e’alone was also associated（Beta:-1.313;95%CI:-2.519,-0.107;P=0.033）.Conclusions:Changes in diastolic function parameters can be observed in Anthracycline patients with hematologic malignancies.The increase of diastolic function parameter E/e’had little relation with the subsequent decrease of systolic function. |
PDF Full Text Request