| Objective:To explore the relationship between NLR and the efficacy and prog nosis of targeted therapy in patients with advanced renal cell carcinoma.Methods:The clinical data of 112 patients with advanced renal cell carcinoma who received targeted therapy in the First Affiliated Hospital of Xinjiang Medical University fro m January 2014 to May 2022 were selected and followed.To analyze the correlati on between NLR and the efficacy and prognosis of targeted therapy in patients wit h advanced renal cell carcinoma.Results: Among the 112 patients followed,the N LR and age cut-off values of ROC curves were 3.655 and 67.5 years,including N LR < 3.655 in 76 cases and NLR ≥ 3.655 in 36 cases,and the results showed th at there was a significant difference between NLR and whether the patients underw ent surgery and distant metastasis before receiving targeted therapy(P<0.05).There were statistically significant differences in age,pathological type,distant metastasis,lymph node metastasis,and efficacy of NLR and targeted therapy(P<0.05).Univa riate analysis showed that there was a certain correlation between the patient’s OS and his age,whether surgery was performed before receiving targeted therapy,path ological type,history of hypertension,distant metastasis,NLR,and lymph node me tastasis,and there were statistical differences(P <0.05)。 The results of multivaria te analysis showed that lymph node metastasis(P=0.002,HR=5.387,95%CI=1.84-15.77),NLR ≥ 3.655(HR=2.375,95%HRCI=1.12-5.034)and age ≥68 years(HR=4.479,95%HRCI=2.049-9.792)were independent risk factors for prognosis(P<0.05).Conclusion: NLR is associated with poor prognosis in patients with advanced renal cell carcinoma.Patients with advanced renal cell carcinoma with baseline NLR<3.655 are more likely to benefit from targeted therapy;In patients with advanced ren al cell carcinoma,lymph nodes,age,and NLR were independent risk factors for pr ognosis. |
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