Effect Of Recombinant Human Brain Natriuretic Peptide On Myocardial Reperfusion Injury After Interventional Intervention For Acute Anterior Myocardial Infarction

Objective:To analyze the effect of recombinant human brain natriuretic peptide(rhBNP)on myocardial reperfusion injury in patients with acute anterior myocardial infarction(AAMI)after percutaneous coronary intervention(PCI).Methods: A total of102 patients with acute anterior wall myocardial infarction were selected from the Second Affiliated Hospital of Xinjiang Medical University.The time from the onset of the selected patients to the completion of PCI was not more than 12 hours.A total of 52 cases were given conventional treatment in the control group and 50 cases in the observation group,given rhBNP on the basis of routine treatment.The occurrence of adverse cardiovascular events during hospitalization was compared between the two groups.cardiac troponin T(cTnT),creatine kinase(CK),creatine Kinase Mb(CK-MB),lactate dehydrogenase(LDH),brain natriuretic peptide(BNP),interleukin-6(IL-6),c-reactive protein(CRP),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)stroke volume(SV)and other indicators were analyzed statistically.Results: Compared with the control group,the patients who were treated with rhBNP were less likely to have malignant arrhythmia during hospitalization(P<0.05),and the indexes of IL-6,CRP,BNP,cTnT,CK,CK-MB,LDH decreased more significantly after treatment(P<0.05).The incidence of recurrent myocardial infarction,cardiogenic shock,mechanical complications,cardiogenic death and LVESD were compared between the two groups during hospitalization.The results showed no significant statistical significance(P>0.05).Conclusion: rhBNP can reduce the severity of reperfusion injury,reduce the level of inflammatory factors,inhibit ventricular remodeling,prevent and treat non-reflow,and improve the prognosis of patients.