Observation On The Therapeutic Effect And Traditional Chinese Medicine Syndrome Types Of Traditional Chinese Medicine Combined With Anlotinib In The Treatment Of Advanced Non-small Cell Lung Cancer

Objective: To observe the efficacy and traditional Chinese medicine syndrome types of traditional Chinese medicine combined with Anlotinib in the treatment of advanced non-small cell lung cancer patients,and provide a certain medication basis for the use of traditional Chinese medicine in patients with advanced non-small cell lung cancer.Method: To summarize and collect patients with advanced non-small cell lung cancer who were treated at the outpatient and inpatient clinics of the Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University from June 2018 to December 2022,and who were taking Anlotinib capsules.They were divided into a treatment group and a control group based on whether they received continuous oral Chinese medicine treatment for ≥ 1 month.Monthly follow-up(until patient death)was conducted to observe the changes in traditional Chinese medicine symptom scores,quality of life ESAS scores,and social function FACT-L scores of the two groups of patients Survival status,traditional Chinese medicine syndrome types,and occurrence of safety events.Result: A total of 63 patients with advanced non-small cell lung cancer were included in this study,of which 42 were included in the treatment group and 21 were included in the control group.The treatment group showed better improvement in traditional Chinese medicine symptom scores,quality of life ESAS scores,and social function FACT-L scores than the control group(P<0.05).The median survival time of the treatment group was 11 months[95%CI(3-18)],while the median survival time of the control group was 7 months[95%CI(5-14)],with no statistically significant difference [P=0.519].The patients in the combined treatment group with traditional Chinese medicine mostly had Qi and Yin deficiency syndrome in the initial stage of enrollment,and Qi and blood deficiency syndrome in the later stage.A total of 25 cases in both groups clearly recorded adverse drug reactions,all of which were common adverse reactions after taking Anlotinib.25 cases did not report discontinuation of the medication due to this situation,and all 63 cases did not find any safety events other than common adverse reactions after taking Anlotinib.Conclusion: The combination of traditional Chinese medicine and Anlotinib can better improve the traditional Chinese medicine symptom scores of patients with advanced non-small cell lung cancer,and also have a certain improvement in their quality of life and social function.The combination of traditional Chinese medicine and Anlotinib in the treatment of advanced non-small cell lung cancer has a trend of prolonging overall survival compared to the treatment with Anlrotinib alone.Patients with advanced non-small cell lung cancer often have both qi and yin deficiency syndrome in middle school,and qi and blood deficiency syndrome in later stage.Therefore,in middle school,more methods of supplementing qi and nourishing yin can be used,and in late stage,more drugs of supplementing qi and nourishing blood can be used.There were no safety events other than adverse reactions caused by the combination of traditional Chinese medicine and Anlotinib in the treatment.