Clinical Characteristics Of Traditional Chinese And Western Medicine In AECOPD Patients With Different Airway Mucus Glucose Content

Objective: To investigate the difference of clinical characteristics of AECOPD patients with different airway mucus glucose content.Methods: A cross-sectional study was conducted to select AECOPD patients admitted to the respiratory department of Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine from December 2021 to February 2023.A total of 102 cases were collected according to the inclusion and exclusion criteria.Sputum samples of patients were collected in the early morning of the next day after admission.The glucose content in sputum was determined by enzyme-related immunosorbent assay(Elisa),and the patients were divided into high level group and low level group according to the median.General data,laboratory test indicators,sputum culture,lung function level,scoring scale,TCM syndrome types and other results of the two groups of study population were collected.Excel was used to establish a database for the above data,and SPSS26.0 statistical software was used to process and analyze the collected data.Results: A total of 51 patients were divided into the low level group(< 0.070774ng/ml)and the high level group(≥0.070774ng/ml)with the median glucose content of 0.070774ng/ml.1.The high level AECOPD patients had higher levels of inflammation indicators PCT and IL-6,more people with abnormally high levels of PCT and CRP,lower levels of lung function DLco SB,relatively higher scores of cough and sputum symptom in CAT assessment,and higher improved British m MRC dyspnea index.The difference was statistically significant(P < 0.05).2.There were no significant differences in other inflammatory indicators,blood gas analysis,glucose and lipid metabolism test results,sputum culture positive detection rate and other lung function indicators between the two groups(P > 0.05).3.TCM syndrome types of the two groups were mainly distributed in phlegm-dampness blocking lung syndrome,followed by phlegm-heat blocking lung syndrome.Conclusions: 1.AECOPD patients with higher ASL glucose content may have a higher level of inflammatory response,and it is especially necessary to pay attention to PCT,IL-6,CRP and other indicators.Cough,sputum,dyspnea and other symptoms are relatively obvious,and the impairment of lung diffusion function is more serious.Lung function examination should be improved as soon as possible and the level of diffusion function should be paid attention to.2.It is speculated that AECOPD patients with higher ASL glucose content have more severe disease.In the later stage,the sample size should be expanded,and the reference value of ASL glucose content in the diagnosis and treatment of AECOPD should be further explored by including stable stage patients and healthy control group to avoid many influencing factors.3.The distribution of TCM syndromes in patients with AECOPD is mainly phlegm-dampness stagnation of lung syndrome,followed by phlegm-heat obstructing lung syndrome.Therefore,in the process of TCM diagnosis and treatment,attention should be paid to "endogenous pathogenic factors",distinguishing the pathogenesis of acute exacerbation based on evidence,and giving consideration to the treatment of "phlegm,turbidity and dampness".