To Analyze The Clinical Features And Traditional Chinese Medicine Syndrome Types Of 60 Cases Of Interstitial Lung Disease With Autoimmune Features

Objectives : The aim of this study is to compare the clinical manifestations,laboratory tests,and imaging manifestations of interstitial lung disease with immune characteristics and connective tissue disease interstitial lung disease,and further summarize the typical characteristics of IPAF,in order to lay the foundation for early detection and diagnosis of IPAF.Methods:This project intends to select 60 cases meeting the diagnostic criteria of IPAF and 80 cases meeting CTD-ILD as controls From January 1,2018 to December 31,2022,and summarize the clinical characteristics and risk factors of death in IPAF by comparing the similarities and differences in general information and clinical manifestations.Results:For general information such as gender,age and smoking history,there was no significant difference between the IPAF and CTD-ILD groups(P>0.05);in terms of pulmonary symptoms,cough and sputum were the most common clinical symptoms in the IPAF group,and arthralgia was the most expressed extra-pulmonary symptom.In contrast,the CTD-ILD group also had cough and sputum,but the proportion of arthralgia and mechanic’s hand was less pronounced than that of the IPAF group.In serological examination,the IPAF group showed the most ANA>1:320,which was significantly different from the CTD-ILD group(P<0.05),and the IPAF group had the most symptoms of ANA>1:320,which was significantly different from the CTD-ILD group(P<0.05),and the two groups had significant differences in RF,anti-SSA and anti-CCP,and the two groups had significant differences in tumor markers The main manifestations of IPAF and CTD-ILD were similar in imaging,while distraction bronchiectasis was more common in the CTD-ILD group,and there was a significant difference between the two groups(P<0.05).there was no significant difference between the IPAF and CTD-ILD groups in blood gas analysis and lung function classification ratio(P>0.05).The common types of symptoms of IPAF were Qi deficiency and blood stasis,phlegm and turbidity congestion in the lung,Qi stagnation and blood stasis,and phlegm and heat stagnation in the lung.The survival of IPAF patients was followed up and logistics regression analysis revealed that the mortality of IPAF patients was closely associated with age >65 years,anti-Jo-1 antibody,foveal focus and severe CO diffusion dysfunction.Conlusions : There were no significant differences between IPAF and CTD-ILD in terms of age,gender and smoking or not.2.In terms of clinical manifestations,IPAF patients had a higher incidence of cough and sputum than CTD-ILD;while CTD-ILD patients had a higher incidence of arthralgias and mechanic’s hands than IPAF patients.3.In terms of serological manifestations,IPAF was mainly characterized by high titers of antinuclear antibodies,while CTD-ILD was mainly characterized by high rates of anti-CCP antibodies and anti-SSA antibodies.CTD-ILD mainly showed high positive rates of rheumatoid factor,anti-CCP antibody and anti-SSA antibody,and the differences between the two groups were statistically significant in ANA > 1:320,positive RF,anti-CCP antibody and anti-SSA antibody;there were no significant differences in the positive rates of tumor markers between the two groups.4.In terms of imaging manifestations,the most common types of manifestations in both groups were foveal foci,grid shadow and distended The incidence of distended bronchial dilatation was higher in the CTD-ILD group than in the IPAF group.5.The common types of symptoms of IPAF are qi deficiency and blood stasis,phlegm turbidity lung evidence,qi stasis blood stasis,and phlegm fever and depression lung evidence.6.Age> 65 years old,anti-Jo-1 antibody,cellular foci,severe CO diffusion dysfunction(DLCO%<40%)are the main causes of increased IPAF mortality.