Explore Professor Xie Jingri’s Experience In Treating Functional Constipation With Tongfu Method Based On Traditional Chinese Medicine Inheritance Computing Platform

Objective:Through a retrospective study of the outpatient medical record data of Professor Xie Jingri’s diagnosis and treatment of patients with functional constipation,Professor Xie Jingri’s medication rules for the treatment of functional constipation were analyzed,its etiology and pathogenesis were explored,and his clinical experience was summarized,in order to provide new ideas for the clinical prevention and treatment of functional constipation.Methods:Collect the first visit cases of functional constipation patients who met the inclusion and exclusion criteria from October 2017 to October 2022,comprehensively collect relevant data,standardize the terminology of the recorded data in advance,and upload it to the Traditional Chinese Medicine Inheritance Assistance Platform(V3.0)for data statistical analysis,traditional Chinese medicine association rule analysis,and cluster analysis.Result:1.A total of 159 patients were included in this study,including 113 women(71%)and 46 men(29%),with more women than men.The age of patients is concentrated 48 to 57 years old,accounting for 50(31.45%).2.In this study,9 types of syndrome were involved,and in order of frequency from high to low,they were qi stagnation(30.19%),Yin deficiency(19.50%),heat accumulation(15.09%),qi deficiency(10.06%),dampness stagnation(9.43%),Yang deficiency(5.66%),blood stasis(5.03%),blood deficiency(3.14%),cold accumulation(1.89%),mainly qi stagnation and Yin deficiency.3.The study collected a total of 143 symptoms,frequency≥10 of 37,among which the top 10 symptoms were:defecation effort,stool time reduction,then out of smooth,sleep poor,dry up,eat less,dry mouth,irritable,abdominal distension,stool sticky.4.In this study,a total of 35 types of tongue images were counted,with the top 5 ranking in order:red tongue,white and greasy tongue coating,dentate tongue,purple and dark tongue coating,and yellow and greasy tongue coating;There were 39 kinds of pulse patterns,8 of which had frequency>5,and the top 5 were:sinking pulse,pulse-chord slip,pulse-slip,fineness of pulse chord and pulse chord.5.In this study,99 single herbs were actually used,including 42 traditional Chinese medicines with a frequency of≥20,ranking the top 20 among them:Fructus Aurantii,Magnolia officinalis,Huomaren,tangerine peel,Yuliren,Atractylodes macrocephala,cardamom,betel nut,cardamom,Scrophulariae,Shenqu,Wuyao,bergamot,perilla seed,Rhubarb,bupleurum,citron,astragalus,malt,hawthorn.6.Statistics on the efficacy of traditional Chinese medicine collected a total of 18 types of drugs,of which the top 6 were:regulating qi,tonifying deficiency,purging diarrhea,resolving dampness,clearing heat,and dissipating food.The frequency of the four qi of traditional Chinese medicine was mainly warm,cold,and flat;The five flavors were mainly bitter,spicy,and sweet;The frequency of meridian tropism of drugs was mainly in the spleen,stomach,lung,large intestine,and liver meridians.7.Through drug association rule analysis,46 drug combinations and 29 drug combinations were obtained under medication mode.As shown in the drug network diagram obtained,a total of 10 drug flavors were involved,and most drug pairs were centered on Fructus aurantii and Magnolia officinalis,such as Fructus aurantii-Magnolia officinalis-Tangerine peel,Fructus aurantii-magnolia officinalis-sesame seed-plum seed,etc.According to data mining of cluster analysis,8 groups of core drug combinations were extracted.Conclusion:1.Professor Xie Jingri summarized the basic pathogenesis of functional constipation as "stagnation of qi and disorder of internal organs".The treatment of functional constipation was based on the fundamental principle of "dredging the internal organs",with differentiation of symptoms and signs,and emphasis on strengthening the circulation of spleen and stomach,regulating liver qi,and intervening and regulating.2.Professor Xie Jingri used the most Qi regulating drugs in the treatment of functional constipation,supplemented by tonifying drugs,diarrhea drugs,etc;The four qi components of the medicine were mainly warm,cold,and flat,while the five flavors were mostly spicy and bitter.They are mainly attributed to the spleen,stomach meridians,followed by the lungs,large intestine,and liver.3.Professor Xie’s commonly used drugs for the treatment of functional constipation include:Fructus Aurantii,Magnolia officinalis,Huomaren,tangerine peel,Yuliren,Atractylodes macrocephala,cardamom,betel nut,white cardamom,Xuanshen,Shenqu,Wuyao,bergamot,purple perilla,rhubarb,bupleurum,citron,astragalus,malt,and hawthorn.