| Objective:To analyze the characteristics of morphological changes in cerebral cortex of children with spastic cerebral palsy and further explore the relationship between morphological changes in cerebral cortex of children with spastic cerebral palsy and gross motor classification system.Methods:(1)A total of 45 SCP children aged 0 to 6 years old diagnosed in the Department of Pediatrics of Bengbu Children’s Hospital from September 2020 to March 2022 were selected as the SCP group,and 45 healthy children with matching gender and age were included as the control group.(2)The whole brain 3D T1 structural images of the subjects were scanned by GE 3.0T magnetic resonance imaging,and the image post-processing was performed by Free Surfer software.The cortical surface area,cortical volume,and cortical thickness were obtained.(3)The motor function of SCP children was graded.(4)The data were summarized and analyzed by Excel and SPSS 26.0 software.The normality of quantitative data was tested first,and the parameters that met the normality were tested by student t test after determining the homogeneity of variance,and were expressed as mean ± standard deviation.Non-normal distribution parameters were compared by Mann-Whitney U test.Chi-square test or Fisher exact test was used for comparison between groups.Spearman rank correlation analysis was used to analyze the correlation between the different brain regions and the motor function grading in SCP group.Results:(1)There were 45 children in SCP group,including 18 full-term infants and 27 premature infants.The number of GMFCS grade Ⅰ to Ⅴ cases was 17,13,7,5 and 3,respectively.There were risk factors in 36 cases and no risk factors in 9 cases.In the control group,45 healthy children were all full-term and in good health.(2)The comparison of general data between the SCP group and the control group showed that there was no statistical significance in gender,age and birth weight between the two groups(P>0.05),but there was statistical significance in birth status,risk factors and MRI plain scan results(P<0.05).(3)The volume of bilateral superior frontal gyrus,right cingulate gyrus,right precuneus,right middle temporal gyrus and left anterior central gyrus in the SCP group was significantly lower than that in the control group(P<0.05).The surface areas of bilateral superior frontal gyrus,right middle temporal gyrus,right middle frontal gyrus,right cingulate gyrus and left anterior central gyrus were significantly lower in SCP group than in control group(P<0.05).The thickness of bilateral superior frontal gyrus,right middle temporal gyrus,right cingulate gyrus and left anterior central gyrus in the SCP group was significantly lower than that in the control group(P<0.05).There were no significant differences in the volume,surface area and thickness of some cortical regions in the SCP group compared with the control group in the same age group(P>0.05).(4)In the SCP group,the morphological characteristics of the bilateral superior frontal gyrus,right middle frontal gyrus,right cingulate gyrus,right middle temporal gyrus,right precuneus and left anterior central gyrus were negatively correlated with the grade of gross motor function,that is,the lower the morphological index of the differential brain area,the higher the GMFCS grade.Conclusion:The cortical volume,surface area and thickness of some cerebral regions in SCP children aged 0-3 years were lower than those in normal children,and some cerebral regions in SCP children aged>3 to 6 years had repair and remodeling after damage.The decrease of the cortical volume,surface area and thickness of the injured brain areas in SCP children was negatively correlated with the motor function grading.With the decrease of the cortical volume,surface area and thickness of these brain areas,the GMFCS grading of children tended to increase(grades I-V). |
PDF Full Text Request