Relationship Between Indoxyl Sulfate Level And Clinical Indexes Of Bone Metabolism In Patients With Chronic Kidney Disease

Objective: Indoxyl Sulfate(IS)is recognized as the representative of enterogenous protein-associated uremic toxin,and the retention of uremic toxin in vivo may be an important cause of organ dysfunction in patients with Chornic kidney disease(CKD).In this study,the changes of serum IS level in patients with CKD in stages 3-5 and 5 were discussed,and the relationship between serum IS level and some clinical indexes of bone metabolism was further discussed.Methods: This study is a prospective study,and the inpatients with CKD who met the inclusion criteria from December 2022 to February 2023 in the Department of Nephrology,the First Affiliated Hospital of Xinjiang Medical University,were analyzed.Their ages were 18-80 years old,and their CKD stages met the diagnostic criteria of chronic kidney disease in KDIGO.Collect patients’ general data and laboratory indexes.All the data were statistically analyzed by SPSS25.0 software.Results:(1)The levels of IS in different stages of CKD were 14.608 0.948 ug/ml in CKD3-4,and 18.514 1.808 um/ml in CKD5(including hemodialysis patients),with statistical significance(P<0.01).Conclusion:(1)The serum IS level of CKD patients gradually increased with the progress of CKD,and reached the peak in CKD5.(2)The serum IS level of 2)CKD patients is mainly related to BMI,dialysis duration,serum creatinine,e GFR,urea nitrogen,serum phosphorus and parathyroid hormone.(3)IS level is positively correlated with ALP level.It IS suggested that the increase of serum is may be an important cause of the occurrence and progress of renal osteopathy and may be one of the intervention targets of its treatment.