Clinicopathological Significance And Survival Analysis Of RNF113A Expression In Esophageal Squamous Cell Carcinoma

Objective:To investigate the expression of RNF113 A in esophageal squamous cell carcinoma and its clinicopathological significance.Methods: Retrospective analysis was made on 100 patients with esophageal squamous cell carcinoma diagnosed from September 2020 to August 2022.Immunohistochemical SP method was used to detect the expression of RNF113 A in 100 esophageal squamous cell carcinoma tissues and 80 paired normal adjacent tissues,as well as the clinical and pathological parameters related to the expression of RNF113 A.Further,Kaplan Meier survival analysis and proportional hazard model COX regression analysis were used to explore the risk factors related to the prognosis and survival of esophageal squamous cell carcinoma patients.Results: In this study,the expression of RNF113 A in 100 esophageal squamous cell carcinoma tissues was up-regulated compared with 80 normal adjacent tissues(P<0.05).The expression of RNF113 A was correlated with clinical stage(P<0.009)and T stage(P=0.015)of esophageal squamous cell carcinoma.Kaplan Meier survival curve showed that there was no statistical significance between the expression of RNF113 A and the prognosis of esophageal squamous cell carcinoma(P>0.05).Univariate analysis showed that sex,clinical stage,T stage,lymph node metastasis and tissue type were the risk factors affecting the overall survival rate of patients with esophageal squamous cell carcinoma.Multivariate analysis suggested that clinical stage,lymph node metastasis and tissue type were independent risk factors for survival and prognosis of esophageal squamous cell carcinoma.Conclusion:RNF113A is highly expressed in esophageal squamous cell carcinoma,and the higher the expression of RNF113 A,the later the clinical stage and T stage of esophageal squamous cell carcinoma patients;Among the patients with RNF113 A positive esophageal squamous cell carcinoma,the male,the later clinical stage and T stage,and the patients with positive lymph node metastasis had low survival rate and poor prognosis.