Correlation Analysis Of Fasting Plasma Glucose Threshold Value And Treatment Regimen In Newly Diagnosed Gestational Diabetes Mellitus

Objective: To investigate the correlation between fasting plasma glucose(FPG)at initial diagnosis and treatment regimen in patients with gestational diabetes mellitus(GDM).Method: Retrospective analysis was performed on the clinical data of 442 pregnant women with GDM who were admitted to our hospital for delivery from December 2019 to December 2022.The patients were grouped according to the starting value of FPG and the selection of treatment plan,and the relevant indicators of the included subjects under different starting value of FPG and different treatment plan were compared.The proportion of pregnant women with different treatment methods under different FPG levels was compared,and the correlation between FPG and insulin treatment in GDM patients was further explored.The cut-off value of FPG for predicting insulin treatment was obtained using receiver ROC curve.Results: 1.The prepregnancy weight,prepregnancy BMI,systolic blood pressure,diastolic blood pressure,OGTT-1h plasma glucose,OGTT-2h plasma glucose,HbA1C and OGTT abnormal indicators were higher in the group with FPG≥6mmol/L.The rate of insulin use in FPG≥6mmol/L group was significantly higher than that in FPG<6mmol/L group.2.Age,FPG at 24-28 weeks of pregnancy,OGTT-1h plasma glucose,OGTT-2h plasma glucose and Hb A1 C were independent risk factors for insulin use(OR>1).The probability of patients using insulin increased 1.587 times for every 1mmol/L increase in FPG(OR=2.587).3.The FPG index predicted whether insulin treatment was effective,and the diagnostic cut-off point of FPG for GDM requiring insulin treatment was 5.97mmol/L.4.When FPG≥6mmol/L in newly diagnosed GDM pregnant women,the incidence of low birth weight infants in the non-insulin group was higher.Conclusions: 1.Compared with FPG<6mmol/L group,the rate of insulin use was significantly higher.2.FPG at 24-28 weeks of gestation was an independent risk factor for insulin use,and was a good predictor of whether insulin was needed.3.There should be the best predictive value of FPG for whether insulin should be used in pregnant women with GDM.When the FPG value is greater than 5.97mmol/L at the first diagnosis,the choice of treatment plan should be vigilant.