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Association Of P16/Ki-67 Expression With Cervical Precancerous Lesions And HPV Infection

Posted on:2024-05-16Degree:MasterType:Thesis
Country:ChinaCandidate:E Z G L Y S M Y L A l z e Full Text:PDF
GTID:2544307085976279Subject:Obstetrics and gynecology
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Objective:To analyze the relationship between the expression levels of P16 and Ki67 and different cervical lesions,and to study the relationship between p16 and Ki67 and HPV infection in patients with cervical precancerous lesions.Methods:176 patients with cervical lesions admitted to the First Affiliated Hospital of Xinjiang Medical University in the past 7 years,aged 24-65 years,were collected and all patients underwent gynecologic liquid-based cytology(TCT),human papillomavirus(HPV)testing,p16/Ki-67double-staining.Results:1.The difference of P16/Ki-67 expression in chronic cervicitis,cervical low-grade intraepithelial neoplasia versus high-grade intraepithelial neoplasia,and cervical malignancy was statistically significant(P<0.01).2.The higher the positive degree of P16 and Ki-67 expression,the greater the incidence of HPV infection,and the difference was statistically significant(P<0.01).3.Ki-67 expression was not significantly different from patients’ age of onset,history of pregnancy and childbirth,menstrual history,mode of delivery,and education(P>0.01).Conclusions:1.With the severity of cervical lesions,the expression of p16 and Ki67 is enhanced,so P16 and Ki-67 can effectively reflect the degree of lesions of cervical intraepithelial neoplasia;2.In the lesions of high-risk HPV infection,especially HPV16/18,p16 and Ki67 are strongly expressed,and the expression of p16 and Ki67 proteins is increased,which can indicate a high risk of HPV infection,so HPV infection is related to p16 and Ki67 expression;3.The dynamic monitoring results of p16 and Ki67 staining can be used as the main biological markers for the early screening and diagnosis of cervical precancerous lesions and cervical cancer.
Keywords/Search Tags:p16,Ki67 immunohistochemical staining, high-grade squamous epithelial lesion of the cervix(HSIL), low-grade squamous intraepithelial lesion of the cervix(LSIL)
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