Effect Of Non-invasive Vagus Nerve Stimulation On Inflammatory Factors In Patients With Coronary Slow Flow

Objective: To study the long-term therapeutic effect of non-invasive vagus stimulation(TS)on patients with coronary slow flow(CSF)and the influence of tragus stimulation on inflammatory factors.Method: Eighty patients diagnosed with CSF by coronary angiography at the Fifth Affiliated Hospital of Xinjiang Medical University from September 2020 to December2022 were randomly assigned to the low-level tragus nerve stimulation group(LL-TS group,n=40)and the control group(N-TS group,n=40),LL-TS group received 80%threshold non-invasive vagus nerve stimulation therapy for 6 months(load 1hour/Bid),N-TS group received non-intensity non-invasive electrical vagus nerve stimulation therapy(load 1hour/Bid),corrected corrected TIMI frame count(CTFC)method was used to calculate coronary blood flow velocity of the two groups before and after the intervention,and the general clinical data were recorded,and the changes of CTFC,the number of angina attacks,severity of angina attacks,and inflammation indexes were analyzed before and after the intervention.Results: The number of blood flow frames in low-level tragus nerve stimulation group was lower than that in control group,the difference was statistically significant(P<o.05)。The levels of serum hs-CRP,TNF-α and interleukin-6 in LL-TS group were lower than those in control group,and the difference was statistically significant(P< o.05).Conclusion: Low-intensity noninvasive vagus nerve stimulation technique may be beneficial to CSF patients by inhibiting inflammatory response.