Analysis Of Risk Factors Related To Canceration Of Laterally Serrated Colorectal Lesions

Objective:To investigate the risk factors for lateral spreading tumors(LST)is Serrated Lesion(SL)combined with High-Grade Intraepithelial Neoplasia(HGIN)or cancerization.Methods:We retrospectively analyzed the clinical data of 105 patients who were diagnosed with LST by colonoscopy at the Gastrointestinal Endoscopy Center of the First Affiliated Hospital of Xinjiang Medical University between January 2020 and December 2021,and the lesions were obtained endoscopically and biopsied in the Department of Pathology.The correlation between the pathological nature of the lesions,general clinical characteristics and endoscopic features was analyzed,and the risk factors associated with LST-type SL combined with HGIN or cancerization were analyzed and summarized.Results:A total of 105 patients with LST-type SL were included,with a mean age of(61.65±12.62)years,61 males and 44 females,and a mean lesion diameter of(26.87±14.40)mm.The location of HGIN or carcinoma was predominantly in distal colon,and LST staging was predominantly nodal mixed type.In univariate analysis,lesion size,morphology,lesion location,aspirin,history of coronary heart disease,history of chronic cholecystitis,and pathology were risk factors associated with LST-type SL combined with HGIN or carcinoma(P<0.05).The Multivariate logistic regression analysis showed that distal colon lesions,history of chronic cholecystitis,history of coronary atherosclerotic heart disease,SSL were independent risk factors for combined HGIN or carcinoma in LST-type SL,while high triglyceride levels were protective factors.Conclusion:This study found that distal colon lesions,lesion diameter≥20mm,chronic cholecystitis,coronary heart disease,pathological type of TSA,and coronary atherosclerotic heart disease were independent risk factors for LST serrated lesions with HGIN or canceration,while high triglyceride levels were protective factors.According to the results,endoscopic physicians should comprehensively assess the patient’s condition in combination with independent risk factors,and perform correct intervention as early as possible to prevent progression of the lesion to cancer.