| Objective:To discuss the factors of persistent infection in high grade intraepithelial lesions(HSIL)with HPV-16,18.Methods:171 patients with HPV-16 and 18 infection were selected from the first Affiliated Hospital of Xinjiang Medical University during June 2019 to December 2021,ten of them were excluded who had a second surgery within 6months after the operation.The remaining 161 people who met the inclusion criteria reviewed HPV infection in 6 months and analyzed influencing factors of persistent infection.Results:After 6 months of follow-up,45 patients with HPV persistent infection(27.95%),116 patients with HPV negative(72.05%).The result of logistic single factor analysis shows that there were significant different in the pathological of the specimen was HSIL,multiple infection,positive margin,gland involvement,lacking lactobacillus,number of leucocyte > 15/HP in the vagina,TCT≥ASC-US(P < 0.05).The results of logistic multivariate analysis showed that the pathological of the specimen was HSIL(OR=3.959),multiple infection(OR=2.928),positive margin(OR=9.911),gland involvement(OR=3.792),lacking lactobacillus(OR=4.773),number of leucocyte>15/HP in the vagina(OR=5.486),TCT≥ASC-US(OR=17.650)were independent risk factors for persistent infection of HPV-16、18 after LEEP in HSIL patients(P<0.05).Conclusions:LEEP does not eliminate all HPV infections,therefore,follow-up should be strengthened for patients with multiple infections,high pathological grade after LEEP,gland involvement,and positive resection margins.Maintaining a normal vaginal microenvironment and paying attention to patients with postoperative TCT abnormalities.These will have the potential to reduce persistent postoperative infections. |
PDF Full Text Request