Current Status Of Latent Tuberculosis Infection And Tuberculosis Awareness Rate Among Freshmen And Their Willingness To Preventive Treatment In Colleges And Secondary Schools In Yining,Xinjiang

Objective: To investigate the basic situation and influencing factors of Latent Tuberculosis Infection(LTBI)among neonates enrolled in colleges and secondary schools in Yining,Xinjiang from 2020 to 2021,at the same time,the awareness rate of core knowledge of tuberculosis prevention and control among freshmen was investigated and its influencing factors were analyzed.In addition,the intention to take prophylactic medication among LTBI freshmen was investigated and the influencing factors were analyzed to provide a theoretical basis for tuberculosis prevention and control in schools of Yining City.Methods: 1)Demographic data,lifestyle,tuberculosis exposure history,ventilation and disinfection in dormitories and classrooms,knowledge of core knowledge of tuberculosis prevention and control and acceptance of preventive medication were collected by questionnaire survey.2)New students 15 years old and above are carried out the tuberculin test(PPD)test and chest X-ray test.PPD test is carried out on students younger than 15 years old,those with suspicious symptoms or strong PPD positive are further performed the X-ray chest X-ray test.Obtain LTBI information in newborn.3)Through univariate analysis and random forest method,important variables were selected and substituted into multiple logistic regression to analyze influencing factors.4)The variables with statistical differences in Logistic regression analysis were introduced as predictive factors,and the clinical prediction model was presented visually in the form of a line graph.The model differentiation was verified by receiver operating characteristic curve(ROC),the calibration curve was used to verify the goodness of fit of the model,and the clinical applicability of the prediction model was evaluated by decision curve analysis.5)The generalized linear model was used to analyze the factors influencing the cognitive score of the core knowledge of tuberculosis prevention and control.Results: 1)A total of 38 schools,including 25 junior high schools,6 senior high schools,6 colleges and technical secondary schools,and 1 undergraduate school,were screened for tuberculosis.39,779 patients should be screened,37,805 patients were actually screened,the effective detection rate was 95.04%,1266 patients were screened for LTBI,the detection rate of LTBI was 3.35%,1 case of active tuberculosis was found,the detection rate of active tuberculosis was 2.65/100,000;2)The results of LTBI multifactor analysis showed that the freshmen drank alcohol(P<0.001,OR=2.421,95%CI: 1.825 ～ 3.211),and the students were from Yining City(P<0.001,OR=3.776,95%CI: 2.471-5.711),other counties and cities in Yili(P<0.001,OR=3.317,95%CI: 2.173～5.063),other prefections in Xinjiang(P<0.001,OR=2.893,95%CI: 1.819～4.430),male(P<0.001,OR=1.329,95%CI:1.110～1.592),had a history of tuberculosis(P<0.001,OR=3.235,95%CI: 2.031～5.155)increased the risk of neonatal LTBI,and knowledge of core TB control knowledge(P<0.001,OR=0.274,95%CI: 0.227～0.330)decreased the risk of LTBI;3)Line graph model: The AUC of the constructed line graph in the training set and the verification set were 0.724 and 0.733,respectively,which proved to have good differentiation,calibration and consistency,and high clinical use value;4)The awareness rate of core knowledge of TB prevention and control among 12592 freshmen was 74.06%,and the awareness rate of core knowledge was 47.67%.Multi-factor analysis results showed that: 19 ～ 12 years of age(β = 0.511,95% CI: 0.237 ～ 0.785),the annual family income is 20000 ～ 40000 yuan(β = 0.330,95% CI: 0.236 ～ 0.424)and more than 40000 yuan(β = 0.480,95% CI:0.238-0.637)had higher awareness of TB.Boys(β = 0.387,95% CI: 0.582 ～ 0.057),and students to yining(β = 0.818,95% CI: 0.960 ～ 0.677),yili prefecture other counties(β =0.890,95% CI: 1.031 ～ 0.748),and other state in xinjiang(β = 0.643,95% CI: 0.783 ～0.502),and the mother with a primary culture and below(β = 0.437,95% CI: 0.637 ～0.238),middle(β = 0.546,95% CI: 0.754 ～ 0.375),high school(β = 0.380,95% CI: 0.572～ 0.188)of the new level of TB is lower.5)The willingness of LTBI patients to receive preventive treatment: 433(78.44%)of newborn LTBI patients were willing to receive preventive treatment.The results of multivariate analysis showed that male students(OR=0.569,95%CI= 0.373-0.868)were more reluctant to receive preventive treatment,and freshmen who knew the core knowledge of TB prevention and control(OR=2.263,95%CI= 1.035-3.793)were more willing to receive preventive treatment.Conclusion:1)Yining college and secondary school freshmen have high LTBI,so more attention should be paid to freshmen who drink alcohol,are from Xinjiang,are male,have a history of tuberculosis,and do not know the core knowledge of tuberculosis prevention and treatment;2)The student LTBI risk prediction model established in this study has been verified and found to have good differentiation,calibration,clinical benefit and prediction ability;3)The total awareness rate of core knowledge of tuberculosis prevention and control among newborn students is lower than the 85% target in the 13 th Five-Year Plan.It is necessary to strengthen the TB health education for newborn students in Xinjiang who are under 16 years old and whose family income is low,so as to improve the awareness rate of core knowledge of tuberculosis prevention and control among students;4)The acceptance rate of preventive treatment for LTBI students is not high,so the importance of preventive treatment should be more comprehensive and in-depth publicity,so as to lay a foundation for the implementation of preventive treatment policy in the future.