The Diagnostic Value Of Albumin Platelet Index (AOI) For Evaluating Liver Fibrosis In Chronic Liver Disease Of Different Etiologies

Objective: To evaluate the diagnostic efficacy of a novel serological marker albumin platelet index(API)on the degree of liver fibrosis in chronic liver disease caused by various etiologies.Methods: 564 patients with chronic liver disease,including 300 patients with noninfectious liver disease and 264 patients with viral liver disease,were chosen for blood biochemical tests and liver biopsies.The patients were then categorized into three groups,based on the international Scheuer grading system: significant fibrosis group(S2),advanced fibrosis group(S3),and cirrhosis group(=S4).The diagnostic value of the API,aspartate-aminotransferase-platelet ratio index(APRI),and fourfactor-based liver fibrosis index(FIB-4)for the degree of liver fibrosis in chronic liver disease of various etiologies was evaluated using the area under the receiver operating characteristic curve(ROC).Results: In the non-infectious liver disease group,the area under the ROC curve(AUROC)of API for diagnosing significant fibrosis,advanced fibrosis,and cirrhosis were 0.75,0.89,and 0.9,respectively,with critical values of 7.71,7.35,and 6.42,respectively.when predicting advanced fibrosis and cirrhosis stages,the AUROC of API was significantly higher than that of APRI and FIB-4(P<0.001),and patients with higher liver The higher the degree of fibrosis,the higher the confidence of the prediction results.In the viral liver disease group,the AUROC of API for diagnosing significant fibrosis,advanced fibrosis,and cirrhosis were 0.77,0.77,and 0.83,respectively,with critical values of 7.32,6.92,and 6.92,respectively.the AUROC of API was significantly higher than APRI and FIB-4 in predicting the stage of cirrhosis(P < 0.05).Conclusion: API is not interfered by age or hepatitis activity level,simple to calculate and more beneficial for clinical application compared with FIB-4 and APRI.In the comparison of the diagnostic efficacy of liver fibrosis in two groups of patients with different etiologies of liver disease,the diagnostic efficacy of API in diagnosing patients with cirrhosis stage was better than that of APRI and FIB-4.the diagnostic efficacy of API in the group of non-infectious liver disease was better than that of hepatic fibrosis in viral hepatitis.the clinical significance of API in the diagnosis of non-infectious liver fibrosis was more significant.