Predictive Value Of The Ratio Of C-reactive Protein To High-density Lipoprotein For Slow Coronary Slow-flow/No Reflow During Emergency Percutaneous Coronary Intervention In Patients With ST-segment Elevation Myocardial Infarction

Objective:This study aimed to investigate the predictive value of plasma CHR on CSF/NRF during emergency PCI in patients with STEMI.Methods:A total of 204 patients with STEMI were consecutively included in this study between January 2021 and October 2021.These patients included were then divided into CSF/NRF and control groups according to the blood flow and myocardial reperfusion status.Relevant data were collected from the CSF/NRF and control groups to compare the difference in relevant data between the two groups.Results:1.A total of 204 patients were included in this study,of which 47 cases(23.0%)experienced CSF/NRF phenomenon.2.Compared with the control group,Older age of the patients in the CSF/NRF group,plasma CHR level,and plasma amino-terminal brain natriuretic peptide precursor(N-terminal prob-type natriuretie peptide,NT-proBNP)peak,creatine kinase isoenzyme(Creatine kinase isoenzyme,CK-MB)peak,troponin Ⅰ(Troponin Ⅰ,TNI)with a higher peak value,large diseased vessel diameter,the total coronary stent length is longer,the proportion of cardiac function Killip grade Ⅱ,thrombus load grade 4,intraoperative thrombus aspiration,and intraoperative hypotension were higher,preoperative blood pressure was significantly lower than the control group(p<0.05),the other variables were not statistically significant(P>0.05).3.Univariate regression analysis showed that age,preoperative cardiac function Killip grade≥Ⅱ,systolic blood pressure at the beginning of surgery,diastolic blood pressure at the beginning of surgery,plasma CHR,CK-MB,cTNI,initial TIMI flow grade≤2,graphic thrombus burden classification≥4,implanted stent diameter,total stent length,intraoperative thrombus aspiration,and intraoperative hypotension were associated with CSF/NRF.Multivariate analysis showed that CHR,cardiac function Killip≥Ⅱ and graphic thrombus burden classification≥4 were independent predictors of the occurrence of CSF/NRF phenomenon.4.ROC curve analysis showed that the plasma CHR level greater than 6.25 was a predictor of CSF/NRF phenomenon,with a sensitivity of 85.1%and a specificity of 69.4%,(AUC=0.784,95%CI:0.717-0.851;P=0.001)Conclusion:For STEMI patients undergoing emergency PCI,plasma CHR level has a high predictive value for the occurrence of intraoperative CSF/NRF phenomenon and can be used as potential biomarkers to identify their occurrence...