| Objectives: To investigate the clinical effects of "blood changing pathological factors removing" stimulant phlebotomy therapy on primary lower extremity varices guided by the theory of zangfu and meridians being unobstructed,by evaluating changes in CEAP clinical s-ymptom grade classification,VCSS clinical manifestation severity score,CIVIQ quality of life survey score,internal diameter of saphenous vein,and saphenous vein reflux time.Methods:Seventy-two patients with primary superficial varicose veins of the lower extremities were included in this study and randomly divided into control and observation groups,36 in each group.The control group was treated with oral Diosmin tablets(450 mg / tablet,2 tablets orally,twice a day),the observation group was treated with Acanthopanax exsanguination therapy(2 treatments per week,3 days apart),and both groups were treated for 4 weeks.Patients in the above two groups underwent lower limb venous color ultrasound before and after treatment to record the internal diameter of the great saphenous vein and the time of venous regurgitation,to record CEAP clinical symptom grade,VCSS clinical manifestation severity score and the CIVIQ quality of life questionnaire.Results:1.Baseline comparison: a final comparison was made of 66 patients with primary superficial varicose veins of the lower extremities,34 in the control group and 32 in the observation group,with both groups of cases homogeneous at baseline and comparable.2.Efficacy results:(1)After treatment,in the observation group,the internal diameter of the great saphen ous vein was smaller than before treatment(P<0.05);After treatment,in the control g-roup,the internal diameter of the great saphenous vein was smaller than before treatment(P<0.05);compared the internal diameter of the great saphenous vein between th-e two groups after treatment,the internal diameter of the great saphenous vein in the observation group was smaller than that in the control group(P<0.05).(2)After treatment the time to the great saphenous vein reflux in the observation group was less than before(P<0.05);after treatment the time to the great saphenous vein reflux in the control group was less than before(P<0.05);compared with the time to the great saphenous vein reflux between the two groups after treatment,the time to re flux was less in the observation group than in the control group(P<0.05).(3)CEAP clinical symptom grade improvement after treatment was better in the obser-vation group than before treatment(P<0.05);CEAP clinical symptom grade improvem-ent after treatment was better in the control group than before treatment(P<0.05);afte-r treatment,compared between the two groups,the improvement of CEAP clinical symptom grade was better in the observation group than in the control group(P<0.05).(4)After treatment the total score of VCSS clinical manifestation severity in the obser vation group was lower than that before treatment(P<0.05);after treatment the tot-al score of VCSS clinical manifestation severity in the control group was lower than that before treatment(P<0.05);the total VCSS clinical manifestation severity scores of the two groups were compared after treatment,and the total VCSS scores of the observati-on group were lower than those of the control group(P<0.05).(5)Comparison of VCSS clinical severity scores before and after treatment in the obs-ervation group showed that the scores for pain,varicose veins,venous edema,and in flammation were lower than before treatment(P<0.05),while the scores for pigmentati on and induration showed no significant difference before and after treatment(P>0.05).Similarly,in the control group,the scores for pain,varicose veins,venous edema,and inflammation were lower than before treatment(P<0.05),while the scores for pig mentation and induration showed no significant difference before and after treatment(P<0.05).Comparison of VCSS clinical severity scores between the two groups after t-reatment showed that the scores for varicose veins and venous edema were lower in the observation group than in the control group(P<0.05),while the scores for pain,p-igmentation,inflammation,and induration showed no significant difference between th-e two groups(P>0.05).(6)After treatment,the CIVIQ quality of life survey score of the observation group was higher than before treatment(P<0.05);the CIVIQ quality of life survey score of the control group was also higher than before treatment(P<0.05);the comparison of CIVIQ quality of life survey scores between the two groups after treatment showed th-at the CIVIQ score of the observation group was higher than that of the control grou-p(P<0.05).Conclusions:1.Both the "Blood changing pathological factors removing" bloodletting therapy and o-ral diosmin can improve the diameter of the great saphenous vein and the reflux time of the great saphenous vein,with the "Blood changing pathological factors removing" bloodletting therapy being superior.2.Both the "Blood changing pathological factors removing" bloodletting therapy and o-ral diosmin can improve the clinical symptoms of primary lower extremity varicose v-eins,with the bloodletting therapy being superior in improving the varicose veins and venous edema symptoms of primary lower extremity varicose veins.3.Both the "Blood changing pathological factors removing" bloodletting therapy and o-ral diosmin can improve the quality of life of patients with primary lower extremity varicose veins,with the "Blood changing pathological factors removing" bloodletting th-erapy being superior. |
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