| Objective:analyze the data of serum biochemical indexes of liver lipid metabolism in different TCM syndromes of non-obese nonalcoholic fatty liver disease,and to explore the distribution characteristics of lipid metabolism related indexes in different TCM syndromes of non-obese NAFLD,so as to provide reference and objective basis for TCM diagnosis and treatment of non-obese NAFLD.Method:The research objects included in this topic are 134 NAFLD patients whose outpatient and inpatient met the criteria of western medicine diagnosis and TCM syndrome differentiation from October 2021 to October 2022 in the Liver Disease Center of Xiamen Hospital of Traditional Chinese Medicine,and whose body mass index was less than 28kg/m2,and were classified according to TCM syndrome differentiation.And collect related clinical data such as sex,age,body mass index,triglyceride,total cholesterol,low-density lipoprotein cholesterol,other serological indicators and imaging indicators,and make statistical analysis with SPSS 23.0software to summarize the relationship between serum TG,TC,LDL-C levels of NAFLD patients and other clinical indicators,and between different TCM syndromes and serum cholinesterase levels.Results:1.Distribution of TCM syndromes in non-obese NAFLD patients.48 cases(35.52%)of phlegm-turbid internal resistance syndrome >43 cases(32.09%)of liver depression and spleen deficiency syndrome > 33 cases(24.63%)of damp-heat accumulation syndrome > 10 cases(7.46%)of phlegm-blood stasis syndrome.The TCM syndrome types of NAFLD are mostly phlegm and turbidity,followed by liver depression and spleen deficiency,damp-heat accumulation,and phlegm and blood stasis are rare.2.Statistics on the distribution differences of related indexes of blood lipid metabolism in non-obese NAFLD patients among TCM syndromes.There was significant difference in the distribution of serum TG and TC levels among TCM syndromes(P < 0.01).There was no significant difference in the distribution of LDL-C among TCM syndromes(P > 0.05).Further pairwise comparison: the serum TG level of non-obese NAFLD was statistically significant(P < 0.01)compared with damp-heat accumulation syndrome,phlegm stagnation syndrome and spleen deficiency syndrome,but not statistically significant(P > 0.05)compared with phlegm stagnation syndrome and phlegm stagnation syndrome and liver stagnation and spleen deficiency syndrome,and the serum TG level was statistically significant(P < 0.05).The serum TC level of non-obese NAFLD was not statistically significant(P > 0.05),while the serum TC level was statistically significant(P < 0.01),and the serum TC level was statistically significant(P < 0.01).To sum up,the distribution of serum TG level in non-obese NAFLD patients is as follows: damp-heat accumulation syndrome,phlegm-blood stasis syndrome > phlegm-turbid internal resistance syndrome > liver depression and spleen deficiency syndrome;The distribution of serum TC level in non-obese NAFLD patients: phlegm and blood stasis syndrome >damp-heat accumulation syndrome,phlegm stagnation syndrome > liver depression and spleen deficiency syndrome.3.Statistics on the distribution differences of general data(age and sexual)of non-obese NAFLD patients among TCM syndromes.There were statistically significant differences in TCM syndromes and gender distribution in non-obese NAFLD patients(P < 0.01),and there were more male patients with liver depression and spleen deficiency,damp-heat accumulation,phlegm-turbidity resistance and phlegm-blood stasis.(2)The age distribution difference of each syndrome type was statistically significant(P < 0.01).Young patients(18-44 years old)were the main syndromes of damp-heat accumulation and phlegm stagnation,young and middle-aged patients(< 59 years old)were the main syndromes of liver depression and spleen deficiency,and middle-aged and elderly patients(≥60 years old)were the main syndromes of phlegm and blood stasis.4.Statistics on the distribution difference of body mass index(BMI)among TCM syndromes of non-obese NAFLD patients.There was significant difference between TCM syndrome types and BMI level in non-obese NAFLD patients(P < 0.01),among which phlegm-turbidity syndrome and phlegm-blood stasis syndrome were the highest.Conclusion:1.The distribution of serum TG level in non-obese NAFLD patients was statistically significant among TCM syndromes.After further pairwise comparative analysis,the distribution of serum TG level of non-obese NAFLD is as follows:damp-heat accumulation syndrome,phlegm-blood stasis syndrome > phlegm-turbid internal resistance syndrome > liver depression and spleen deficiency syndrome;2.The distribution of serum TC level in non-obese NAFLD patients was statistically significant among TCM syndromes.The distribution of serum TC level: phlegm and blood stasis syndrome > damp-heat accumulation syndrome,phlegm stagnation syndrome > liver depression and spleen deficiency syndrome.3.There was no significant difference in the distribution of serum LDL-C in non-obese NAFLD patients among TCM syndromes. |
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