| Purpose:Through systematic study,observe the clinical efficacy of Guchong Zhijing prescription in the treatment of prolonged menstrual period of Qi deficiency and blood stasis type,and compare it with Buzhong Yiqi Pill + Notoginseng.Observe the changes of patients’ menstruation time before and after treatment,the changes of TCM syndrome score and the recurrence after 1 month’s follow-up.Objective To evaluate the clinical effectiveness and safety of Guchong Zhijing prescription in the treatment of prolonged menstrual period with Qi deficiency and stasis.Methods :In this study,66 patients were selected strictly according to the established inclusion and exclusion criteria,and randomly divided into the treatment group(32 cases)and the control group(34 cases).Both groups started taking medicine on the 4th day of menstruation and treated for 10 days as a course of treatment.The treatment group was treated with Guchong Zhijing prescription,while the control group was treated with Buzhong Yiqi Wan plus pantoginseng.The two groups received continuous medication for10 days and two menstrual cycles.The duration of menstruation and related symptoms before and after medication were scored and recorded,and the clinical data were analyzed and processed by SPSS 26.0 statistical software.To summarize the clinical effect of Guchong Zhijing prescription on prolonged menstrual period of Qi deficiency and blood stasis type.Results:1.A total of 66 cases of prolonged menstruation with Qi deficiency and blood stasis were included in this study: 32 cases in the treatment group and 34 cases in the control group.Baseline data such as age,marital history,course of disease,B-ultrasound examination data and disease grade of the two groups were statistically comparable(P >0.05).2.Statistical tests were conducted on the duration of menstration,scores of various TCM symptoms,TCM syndrome scores and disease evaluation of the two groups before treatment,all of which were comparable(P>0.05).3.The duration of menstruation before treatment was 10.97±1.91 in the two groups,and 11.47±1.90 in the control group.The duration of menstruation before and after treatment was compared between the two groups(X±S): after the end of the first course of treatment,the duration of menstruation in the treatment group was 8.34±1.23,9 patients had their menstruation shortened to 7 days,and the duration of menstruation in the control group was 10.03±2.04,3.The duration of menstruation before treatment was 10.97±1.91 in the two groups,and 11.47±1.90 in the control group.Comparison of the duration of menstruation before and after treatment between the two groups: after the first course of treatment,the duration of menstruation in the treatment group was 8.34±1.23,9 patients had their menstruation shortened to 7 days,and the duration of menstruation in the control group was 10.03±2.04,3 patients had their menstruation shortened to 7 days.After the second course of treatment,the duration of menstruation in the treatment group was 6.72 ± 1.42,the duration of menstruation in the treatment group was 8.38±2.31,and the duration of menstruation in the control group was 8.38 ± 2.31,and the menstrual cycle in 41% of patients was shortened to within 7 days.There were significant differences between the treatment group and the control group in the improvement of menstruation time before and after treatment(P < 0.01).The therapeutic effect of the treatment group was statistically different from that of the control group(P < 0.01).After two courses of treatment,the effective rate of treatment for diseases with prolonged periods: In the treatment group,15 cases(46.88%)were cured,16 cases(50%)were effective,and 1 case(3.12%)were ineffective,with a total effective rate of 96.88%;in the control group,0 cases(0%)were cured,25 cases(73.53%)were effective,and 9 cases(26.47%)were ineffective,with a total effective rate of 73.53%.Chi-square test showed that p value was 0.008.There was a statistical difference between the two groups.4.After the two courses of treatment,statistical analysis was carried out on the scores of the two groups of patients respectively,which showed that the scores of the two groups of patients had decreased,among which,the scores of the time degree of menstruation,menstrual color,blood clots,limb fatigue and exhaustion,spontaneous sweating,and lower abdominal tingling during menstruation were compared with those before treatment,P<0.05,and the differences were statistically significant.Compared with before treatment,there was no significant difference in the score of astringency in the two groups(X±S)(P >0.05).By comparison between groups,there were statistically significant differences in the scores of time degree of menstruation,limb fatigue,spontaneous sweating and scores of lower abdominal tingling after menstruation between the two groups(P < 0.05).The scores of menstruation color,blood clot and astringency obstruction during menstruation between the two groups were compared between the two groups(P > 0.05),indicating no difference in efficacy.5.After the treatment of two menstrual cycles,TCM disease efficacy score was used to calculate the TCM comprehensive efficacy rate of the two groups: In the treatment group,1 case(3.13%)was cured,27 cases(84.38%)were obviously effective,4 cases(12.5%)were effective,0 cases(0%)were ineffective,and the total effective rate was 100%.In the control group,0 cases(0%)were cured,4 cases(11.76%)were obvious,17 cases(50.00%)were effective,13 cases(38.24%)were ineffective.The total effective rate was 61.76%.Through the test,there were significant differences in the evaluation results of TCM comprehensive curative effect between the two groups after treatment(c2=15.236,p <0.001),and the effective situation of the treatment group was better than that of the control group.6.After the two courses of treatment,32 patients in the treatment group and 34 patients in the control group were followed up for 1 menstrual cycle,and the duration of menstruation of the two groups was recorded: After drug withdrawal,26 of the 32 patients in the treatment group had menstruation within 7 days,6 patients had menstruation within8-9 days,and 9 of the 34 patients in the control group had menstruation within 7 days,while 6 patients had menstruation within 8-9 days,10 patients had 10-12 days,and 9patients had 13-14 days.According to the test,there was a significant difference between the two groups(p < 0.01).The maintenance of menstrual period in the treatment group was better than that in the control group after drug withdrawal.7.During treatment,no special adverse reactions were found in both groups.Conclusions:1.Guchong Zhijing formula can shorten the duration of menstruation of patients with Qi deficiency and blood stasis,and has a low recurrence rate after drug withdrawal.2.Guchong Zhijing can improve the symptoms of menstruation,blood clots,limb fatigue and fatigue,spontaneous sweating,tingling in the lower abdomen during menstruation.3.Compared with Buzhong Yiqi pills + Notoginseng,Guchong Zhijing prescription has superior clinical efficacy and good safety in the treatment of prolonged menstrual period of Qi deficiency and blood stasis... |
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