Effect Of Low-frequency Repetitive Transcranial Magnetic Stimulation On Emotional Regulation In Adolescent Patients With Depression And Non-suicidal Self-injury

Objective:To explore the effect of low-frequency repetitive transcranial magnetic stimulation(r TMS)on the right dorsolateral prefrontal cortex(r DLPFC)on emotion regulation in adolescent patients with depression and non-suicidal self-injury,and further study the mediating role of cognitive emotion regulation strategies in improving non-suicidal self-injury with low-frequency repetitive transcranial magnetic stimulation.To provide clinical reference for improving emotional regulation and reducing self-injury in adolescent patients with depression and non-suicidal self-injury.Method:A total of 60 adolescent patients with depression and non-suicidal self-injury were selected as research objects according to inclusion and exclusion criteria,and randomly divided into experimental group and control group.The research adopted a single blind experiment.The experimental group received low-frequency r TMS true stimulation 5times a week for 2 weeks on the basis of fluoxetine hydrochloride drug therapy and general psychotherapy;In addition to fluoxetine hydrochloride and general psychotherapy,the control group received low-frequency r TMS pseudo-stimulation 5times a week for 2 weeks.Before and after intervention,the general demographic data questionnaire,Self-rating Depression Scale(SDS),Cognitive Emotion Regulation Questionnaire(CERQ),Difficulties in Emotion Regulation Scale(DERS)and Adolescent Non-suicidal Self-injury Assessment Questionnaire(ANSSIQ)were used to evaluate the two groups of subjects.Result:1.After intervention,the scores of the experimental group on SDS,CERQ(positive),CERQ(negative),DERS and ANSSIQ scales were significantly different from those before intervention(p < 0.001).2.After intervention,the scores of the experimental group on SDS,CERQ(negative),DERS and ANSSIQ scales were significantly lower than those of the control group,and the CERQ(positive)scores were significantly higher than those of the control group(p < 0.05).3.The mediating effect value of CERQ(negative)score variation,as the mediating variable for the reduction of NSSI behavior by low-frequency r TMS,was-0.2510,95%CI was(-0.5686,-0.0145),indicating a significant mediating effect.4.The mediating effect value of CERQ(negative)score variation,as the mediating variable of low-frequency r TMS reducing the intention of NSSI,was-0.1944,95%CI was(-0.4392,-0.0100),indicating a significant mediating effect.Conclusion:1.Low-frequency r TMS stimulation on r DLPFC can effectively improve the depression mood of adolescent patients with depression and non-suicidal self-injury,improve the tendency to use positive cognitive emotion regulation strategies,reduce the tendency to use negative cognitive emotion regulation strategies,improve the difficulty in emotional regulation.2.Low-frequency r TMS stimulation on r DLPFC can effectively reduce the selfinjury behavior and intention of self-injury in adolescents with depression and nonsuicidal self-injury.3.Negative cognitive emotion regulation strategies plays a mediating role in the low-frequency r TMS stimulating r DLPFC to reduce the behavior of self-injury and the intention of self-injury.Specifically,low-frequency r TMS stimulating r DLPFC to reduce the behavior of self-injury and the intention of self-injury by reducing the tendency to use negative cognitive emotion regulation strategies.