Effects Of Helicobacter Pylori Eradication On Esophageal Motility,Esophageal Acid Exposure,and Gastroesophageal Reflux Disease Symptoms

Objective: The objective of this study was to explore the effects of Helicobacter pylori(Hp)eradication on esophageal motility,esophageal acid exposure,and gastroesophageal reflux disease(GERD)symptoms.Method: This study was an experimental and self-controlled study.108 patients diagnosed with both GERD and Hp were recruited from August 2021 to August 2022.High resolution esophageal manometry(HREM),24-hour esophageal pH monitoring,and the Gastroesophageal Reflux Disease Questionnaire(GerdQ)was performed before and after the successful eradication of Hp,and the data of HREM parameters:integrated relaxation pressure(IRP),distal contractile integral(DCI),lower esophageal sphincter pressure(LESP),percentage of ineffective swallowing and percentage of large peristalsis break;24-hour pH monitoring parameters: the percentage of acid exposure time(AET%),De Meester score,longest reflux event,the number of reflux episodes,and GerdQ score were compared using statistical analysis.Result: 1.70 cases diagnosed with both GERD and Hp infection were finally included.2.The After Hp eradication group showed significantly decreased median DCI [673.10(440.15,1104.98)mm Hg·s·cm VS 544.75(247.60,787.15)mm Hg·s·cm] and LESP [6.95(3.90,9.58)mm Hg VS 5.15(2.45,8.20)mm Hg],and significantly increased of ineffective swallowing [16.50(0.00,50.00)% VS 27.00(7.50,82.00)%] in the HREM compared with the Before Hp eradication group(P<0.05).3.The 24-hour esophageal pH monitoring showed that AET% [9.15(6.90,13.20)% VS 10.37(7.88,15.60)%],the De Meester score [37.60(27.18,63.38)VS 46.30(34.58,65.15)],the number of reflux episodes[68.00(50.50,87.50)VS 77.00(57.00,90.00)] and the longest reflux event[12.00(8.75,15.00)VS14.50(9.50,18.00)],were all significantly different between the Before and After Hp eradication groups(P<0.05).4.The After Hp eradication group also had a significantly higher GerdQ score [10.00(10.00,12.00)VS11.00(10.00,13.00)] than the Before Hp eradication group(P < 0.05).Conclusion: Hp eradication reduced esophageal peristalsis and LESP,enhanced esophageal acid exposure and aggravated GERD symptoms,suggesting that Hp eradication may be a risk factor for GERD.