Study On Correlation Between TCM Syndrome Types And Neuroelectrophysiological Indexes Of Diabetes Peripheral Neuropathy

Objective: By analyzing the differences of the neuroelectrophysiological indicators of the TCM syndrome types in different stages of diabetes peripheral neuropathy(DPN,The patients can be preliminarily classified into corresponding syndrome types under corresponding stages according to abnormal electrophysiological indicators and clinical symptoms.Or the degree of nerve injury can be preliminarily predicted by analyzing the TCM syndrome types of patients,so as to provide objective indicators with reference value for the next diagnosis and treatment plan.Methods: The selected subjects were determined according to the diagnostic criteria of diabetes and diabetes peripheral neuropathy;According to the diagnostic criteria of TCM syndrome types,the selected subjects were divided into three groups: qi deficiency and blood stasis,yin deficiency and blood stasis,qi yin deficiency and blood stasis,yin yang deficiency and phlegm stasis,yang deficiency and cold coagulation,liver and kidney deficiency.All patients were examined by electromyography,motor nerve conduction velocity(MCV),sensory nerve conduction velocity(SCV),amplitude of compound muscle action potential(CMAP)and amplitude of sensory nerve action potential(SNAP)were detected respectively;Neuroelectrophysiological test objects include median nerve,ulnar nerve,common peroneal nerve and sural nerve.The age,course of disease,Hb A1 c,FBG and PBG were recorded.Analysis of variance and t-test were used for correlation statistical analysis to explore the relationship between TCM syndrome types and neuroelectrophysiology,age,course of disease,Hb A1 c,FBG and PBG.Results:Compared with the duration of each syndrome type,there was a significant difference between the yang deficiency and cold coagulation type and the qi yin deficiency type(P<0.01).The qi yin deficiency type was the shortest,followed by the yang deficiency and cold coagulation type,and the liver and kidney deficiency type was the longest;The results of FBG,PBG and glycosylated hemoglobin in each syndrome type were higher than the normal values(P<0.01).The muscular atrophy type was the highest,followed by the pain stage,and the numbness stage was the lowest;Compared the amplitude of MCV,CMAP and SNAP among different syndrome types,there were significant differences between muscle atrophy stage,pain stage and numbness stage,and median nerve was the most obvious;Compared with the pain and numbness periods,the SCV in the muscular atrophy period was significantly different among the groups,and the sural nerve was the most obvious.Conclusion: There are differences in the electrophysiological examination of different TCM syndromes of diabetes peripheral neuropathy,and there are significant differences in the detection data of MCV,SCV,CMAP amplitude and SNAP amplitude among different syndromes.Neuroelectrophysiology is a sensitive indicator for observing peripheral neuropathy,and it may be one of the objective reference indicators for TCM classification research and intervention treatment of diabetes peripheral neuropathy,which is worth further research and promotion.