Study On The Related Risk Factors And TCM Syndrome Characteristics Of Post-stroke Depression

Objective: To explore the related risk factors and traditional Chinese medicine(TCM)syndrome characteristics of post-stroke depression(PSD),so as to provide theoretical reference for the prevention and treatment of post-stroke depression,so as to promote the comprehensive recovery of body function and physical and mental health of patients and improve the quality of life.Methods: A total of 295 stroke patients in the recovery stage who met the inclusion and exclusion criteria in the encephalopathy treatment area of the Third Affiliated Hospital of Changchun University of Traditional Chinese Medicine were selected.According to HAMD Hamilton depression scale(17)assessment is divided into depression group(7 or higher)and depression(< 7),records of two groups of patients with demographic information(gender,age,marital status,educational level,economic status,personality,the recent negative event),the relevant medical history of stroke(type of stroke,stroke,stroke frequency and stroke duration).History of cerebrovascular risk(history of hypertension,diabetes,History of carotid artery plaque,hyperlipidemia,coronary heart disease)and stroke rehabilitation(stroke scale NIHSS score,modified Rankin scale score,upper and lower limb Fugl-Meyer motor function score,Barthel Index score,Lawton functional score,Family care index score,social support score),The clinical data of the two groups were analyzed by univariate analysis and logistic regression analysis to explore the risk factors of PSD.At the same time,the main symptoms,tongue and pulse of patients in the depression group were collected,and the TCM syndrome collection table was completed.Cluster analysis was performed on the four diagnosis information to analyze the TCM syndrome characteristics of PSD.Results:1.The number of patients with depression and non-depression were 126 and 169,respectively.The total incidence of PSD was 42.7%,including 54 patients with mild depression(42.86%),48 patients with moderate depression(38.10%)and 24 patients with severe depression(19.05%).2.Univariate analysis showed that there were statistically significant differences in gender,number of strokes,history of carotid plaque,Fugl-Meyer score of upper limb,Barthel index score,and family care index score between the two groups(P<0.05).Age,marital status,education,economic status,personality,recent negative events,stroke type,stroke location,stroke duration,history of hypertension,history of diabetes,There were no significant differences in the history of hyperlipidemia,coronary heart disease,NIHSS score,modified Rankin score,lower limb Fugl-Meyer score,Lawton functional score,and social support score between the two groups(P>0.05).3.Logistic regression analysis showed that gender and the number of strokes were the protective factors of PSD(OR<1),while the history of carotid plaque,upper limb motor function,activities of daily living,and family function were the risk factors of PSD.(OR>1).4.TCM syndrome cluster analysis showed that the TCM syndromes of PSD patients could be divided into the following four categories: liver and kidney deficiency,liver stagnation and fire,liver stagnation and spleen deficiency,and mutual obstruction of phlegm and blood stasis.Conclusion:1.The incidence of post-stroke depression is relatively high,and the gender of patients,stroke frequency,carotid plaque history,upper limb motor function level,daily living ability and family function status are all related risk factors affecting the occurrence of post-stroke depression,which can be prevented clinically.2.TCM syndroms of post-stroke depression can be roughly divided into the following four categories: deficiency of liver and kidney,liver depression turning fire,liver depression and spleen deficiency,phlegm-stasis mutual obstruction.The occurrence of post-stroke depression is closely related to the function state of the liver,heart,spleen,kidney and other viscera,which can be treated clinically accordingly.